GATA-1 and PU.1 are transcription factors that control erythroid and myeloid development, respectively. The two proteins have been shown to function in an antagonistic fashion, with GATA-1 repressing PU.1 activity during erythropoiesis and PU.1 repressing GATA-1 function during myelopoiesis. It has also become clear that this functional antagonism involves direct interactions between the two proteins. However, the molecular basis for these interactions is not known, and a number of inconsistencies exist in the literature. We have used a range of biophysical methods to define the molecular details of the GATA-1-PU.1 interaction. A combination of NMR titration data and extensive mutagenesis revealed that the PU.1-Ets domain and the GATA-1 C-t...
In many hematopoietic malignancies such as lymphomas and leukemias, aberrant differentiation is the ...
All 3 hematopoietic GATA transcription factors, GATA-1, GATA-2, and GATA-3, are acetylated, although...
GATA factors orchestrate hematopoiesis via multistep transcriptional mechanisms, but the interrelati...
GATA-1 and PU.1 are transcription factors that control erythroid and myeloid development, respective...
The GATA-1 transcription factor is capable of suppressing the myeloid gene expression program when e...
The GATA-1 transcription factor is ca-pable of suppressing the myeloid gene expression program when ...
Haematopoiesis is the process of blood cell formation from self-renewing haematopoietic stem cells ...
In many hematopoietic malignancies such as lymphomas & leukemias, aberrant differentiation is t...
Hematopoiesis is coordinated by a complex regulatory network of transcription factors among them PU....
Hematopoiesis is coordinated by a complex regulatory network of transcription factors among them PU....
GATA-1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and mast cell ...
etic transcription factors that control erythromegakaryocytic and myelolym-phoid differentiation, re...
GATA1 and KLF1 are transcription factors that regulate genes which are important for the development...
<div><p>GATA-1 and PU.1 are two important hematopoietic transcription factors that mutually inhibit ...
PU.1 is a hematopoietic transcription factor that is required for the development of myeloid and B c...
In many hematopoietic malignancies such as lymphomas and leukemias, aberrant differentiation is the ...
All 3 hematopoietic GATA transcription factors, GATA-1, GATA-2, and GATA-3, are acetylated, although...
GATA factors orchestrate hematopoiesis via multistep transcriptional mechanisms, but the interrelati...
GATA-1 and PU.1 are transcription factors that control erythroid and myeloid development, respective...
The GATA-1 transcription factor is capable of suppressing the myeloid gene expression program when e...
The GATA-1 transcription factor is ca-pable of suppressing the myeloid gene expression program when ...
Haematopoiesis is the process of blood cell formation from self-renewing haematopoietic stem cells ...
In many hematopoietic malignancies such as lymphomas & leukemias, aberrant differentiation is t...
Hematopoiesis is coordinated by a complex regulatory network of transcription factors among them PU....
Hematopoiesis is coordinated by a complex regulatory network of transcription factors among them PU....
GATA-1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and mast cell ...
etic transcription factors that control erythromegakaryocytic and myelolym-phoid differentiation, re...
GATA1 and KLF1 are transcription factors that regulate genes which are important for the development...
<div><p>GATA-1 and PU.1 are two important hematopoietic transcription factors that mutually inhibit ...
PU.1 is a hematopoietic transcription factor that is required for the development of myeloid and B c...
In many hematopoietic malignancies such as lymphomas and leukemias, aberrant differentiation is the ...
All 3 hematopoietic GATA transcription factors, GATA-1, GATA-2, and GATA-3, are acetylated, although...
GATA factors orchestrate hematopoiesis via multistep transcriptional mechanisms, but the interrelati...