Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.

  • Isaacs, JD
  • Hazleman, BL
  • Chakravarty, K
  • Grant, JW
  • Hale, G
  • Waldmann, H
Publication date
June 1996
Journal
The Journal of Rheumatology

Abstract

A worker in a polyvinyl chloride factory with rapidly progressive diffuse cutaneous scleroderma was treated with the humanized monoclonal antibody (Mab) CAMPATH-1H. Treatment was followed by rapid and substantial improvement in skin score, which was maintained during followup without additional therapy. The mode of action of CAMPATH-1H and its relationship to clinical improvement are discussed

Extracted data

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