Add to ORKGDuring severe hypoxia (<0.01% oxygen) the protein folding machinery becomes dysfunctional, resulting in the accumulation of unfolded proteins with consequent endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) and autophagy, a process involved in the physiological turnover of cytoplasmic components. The link between the UPR and autophagy is not clearly defined. The aim of this thesis is to investigate the role of the induction of UPR under severe hypoxia in tumour survival and resistance to therapy. The results of this research suggest that the activating transcription factor 4 (ATF4), a component of the PKR-like ER kinase (PERK) pathway, fundamental in the UPR, is required for the ER-stress induced upreg...
It is evident that regions within tumors are deprived of oxygen, which makes the microenvironment hy...
The ubiquitin-proteasome system plays a key regulatory role in cellular homeostasis. The inhibition ...
© 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pat...
During severe hypoxia (<0.01% oxygen) the protein folding machinery becomes dysfunctional, resulting...
Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and ...
Cancer cells survive the harsh oxygen and nutrient deprivation of the tumour microenvironment throug...
Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progr...
Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and tr...
The unfolded protein response (UPR) is a stress response activated by the accumulation of unfolded o...
In the tumor microenvironment, cancer cells experience hypoxia resulting in the accumulation of misf...
Low oxygenation, or hypoxia, is prevalent in human solid tumours and is a known contributor to thera...
Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and tr...
Introduction: The hypoxia-inducible factor (HIF)-1 pathway can stimulate tumor cell migration and me...
It is evident that regions within tumors are deprived of oxygen, which makes the microenvironment hy...
The ubiquitin-proteasome system plays a key regulatory role in cellular homeostasis. The inhibition ...
© 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pat...
During severe hypoxia (<0.01% oxygen) the protein folding machinery becomes dysfunctional, resulting...
Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and ...
Cancer cells survive the harsh oxygen and nutrient deprivation of the tumour microenvironment throug...
Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progr...
Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and tr...
The unfolded protein response (UPR) is a stress response activated by the accumulation of unfolded o...
In the tumor microenvironment, cancer cells experience hypoxia resulting in the accumulation of misf...
Low oxygenation, or hypoxia, is prevalent in human solid tumours and is a known contributor to thera...
Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and tr...
Introduction: The hypoxia-inducible factor (HIF)-1 pathway can stimulate tumor cell migration and me...
It is evident that regions within tumors are deprived of oxygen, which makes the microenvironment hy...
The ubiquitin-proteasome system plays a key regulatory role in cellular homeostasis. The inhibition ...
© 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pat...