Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.

Hoppenbrouwers, IA
Aulchenko, YS
Janssens, AC
Ramagopalan, SV
Broer, L
Kayser, M
Ebers, GC
Oostra, BA
van Duijn, CM
Hintzen, RQ

Open link

Publication date

November 2009

DOI

10.1038/jhg.2009.96

Publisher

Springer Science and Business Media LLC

Journal

Journal of Human Genetics

Abstract

A recent genome-wide association study by the International Multiple Sclerosis Genetics Consortium (IMSGC) reported association of 17 single-nucleotide polymorphisms (SNPs) in 14 loci with multiple sclerosis (MS). Only two loci, HLA-DRA and IL2RA, reached genome-wide significance (P<5E-08). In our study, we determined whether we could replicate the results of the IMSGC and whether more SNPs are genome-wide significantly associated with MS. We assessed the association between the 17 IMSGC SNPs and MS in three cohorts (total number of subjects 3981, among these 1853 cases). We performed a meta-analysis of the results of our study, the original IMSGC results and the results of a recent replication study performed in the Australian population. ...