Monte Carlo evaluation of radionuclides for early brain metastases targeting

Metastasis of breast cancer to the brain presents a pressing therapeutic challenge. Vascular cell adhesion molecule 1 (VCAM‐1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. We have developed a Monte Carlo model representing brain vasculature to evaluate the efficacy of a variety of potential therapeutic nuclides; alpha‐emitters: 149Tb, 211At, 212Pb, 213Bi and 225Ac; beta and Auger electron‐emitters: 90Y, 161Tb and 177Lu, 67Ga, 89Zr, 111In and 124I for targeted radionuclide therapy (TRT)