Homocystinuria is an inborn error of methionine metabolism that results in raised serum levels of the highly reactive thiol-containing amino acid homocysteine. Homocystinurics often exhibit phenotypic abnormalities that are similar to those found in Marfan syndrome (MFS), a heritable connective tissue disorder that is caused by reduced levels of, or defects in, the cysteine-rich extracellular matrix (ECM) protein fibrillin-1. The phenotypic similarities between homocystinuria and MFS suggest that elevated homocysteine levels may result in an altered function of fibrillin-1. We have used recombinant calcium binding epidermal growth factor-like (cbEGF) domain fragments from fibrillin-1, and an unrelated protein Notch1, to analyse the effects ...
<div><p>One of the proposed mechanisms of homocysteine toxicity in human is the modification of prot...
SummaryFibrillin-1 (FBN1) contains 47 epidermal growth factor (EGF)–like domains characterized by si...
Homocysteine is a non-proteinogenic amino acid playing key roles in two interconnected metabolic pat...
Homocystinuria is an inborn error of methionine metabolism that results in raised serum levels of th...
Fibrillin-1 is a 350 kDa calcium-binding protein which assembles to form 10-12 nm microfibrils in th...
The largest group of disease-causing mutations affecting calcium-binding epidermal growth factor-lik...
Fibrillin-1 is a major glycoprotein component of 10-12 nm microfibrils, consisting predominantly of ...
SummaryFibrillin-1 (FBN1) contains 47 epidermal growth factor (EGF)–like domains characterized by si...
The calcium-binding epidermal growth factor-like (cbEGF) module and the transforming growth factor ?...
One of the proposed mechanisms of homocysteine toxicity in human is the modification of proteins by ...
The calcium-binding epidermal growth factor-like (cbEGF) module and the transforming growth factor b...
The calcium-binding epidermal growth factor-like (cbEGF) module and the transforming growth factor b...
Fibrillin-1 is a mosaic protein mainly composed of 43 calcium binding epidermal growth factor-like (...
Fibrillin-1 is a mosaic protein mainly composed of 43 calcium binding epidermal growth factor-like (...
Fibrillin-1 is a mosaic protein mainly composed of 43 calcium binding epidermal growth factor-like (...
<div><p>One of the proposed mechanisms of homocysteine toxicity in human is the modification of prot...
SummaryFibrillin-1 (FBN1) contains 47 epidermal growth factor (EGF)–like domains characterized by si...
Homocysteine is a non-proteinogenic amino acid playing key roles in two interconnected metabolic pat...
Homocystinuria is an inborn error of methionine metabolism that results in raised serum levels of th...
Fibrillin-1 is a 350 kDa calcium-binding protein which assembles to form 10-12 nm microfibrils in th...
The largest group of disease-causing mutations affecting calcium-binding epidermal growth factor-lik...
Fibrillin-1 is a major glycoprotein component of 10-12 nm microfibrils, consisting predominantly of ...
SummaryFibrillin-1 (FBN1) contains 47 epidermal growth factor (EGF)–like domains characterized by si...
The calcium-binding epidermal growth factor-like (cbEGF) module and the transforming growth factor ?...
One of the proposed mechanisms of homocysteine toxicity in human is the modification of proteins by ...
The calcium-binding epidermal growth factor-like (cbEGF) module and the transforming growth factor b...
The calcium-binding epidermal growth factor-like (cbEGF) module and the transforming growth factor b...
Fibrillin-1 is a mosaic protein mainly composed of 43 calcium binding epidermal growth factor-like (...
Fibrillin-1 is a mosaic protein mainly composed of 43 calcium binding epidermal growth factor-like (...
Fibrillin-1 is a mosaic protein mainly composed of 43 calcium binding epidermal growth factor-like (...
<div><p>One of the proposed mechanisms of homocysteine toxicity in human is the modification of prot...
SummaryFibrillin-1 (FBN1) contains 47 epidermal growth factor (EGF)–like domains characterized by si...
Homocysteine is a non-proteinogenic amino acid playing key roles in two interconnected metabolic pat...