Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.
- Beaumont, RN
- Warrington, NM
- Cavadino, A
- Tyrrell, J
- Nodzenski, M
- Horikoshi, M
- Geller, F
- Myhre, R
- Richmond, RC
- Paternoster, L
- Bradfield, JP
- Kreiner-Møller, E
- Huikari, V
- Metrustry, S
- Lunetta, KL
- Painter, JN
- Hottenga, J-J
- Allard, C
- Barton, SJ
- Espinosa, A
- Marsh, JA
- Potter, C
- Zhang, G
- Ang, W
- Berry, DJ
- Bouchard, L
- Das, S
- Hakonarson, H
- Heikkinen, J
- Helgeland, Ø
- Hocher, B
- Hofman, A
- Inskip, HM
- Jones, SE
- Kogevinas, M
- Lind, PA
- Marullo, L
- Medland, SE
- Murray, A
- Murray, JC
- Njølstad, PR
- Nohr, EA
- Reichetzeder, C
- Ring, SM
- Ruth, KS
- Santa-Marina, L
- Scholtens, DM
- Sebert, S
- Sengpiel, V
- Tuke, MA
- Vaudel, M
- Weedon, MN
- Willemsen, G
- Wood, AR
- Yaghootkar, H
- Muglia, LJ
- Bartels, M
- Relton, CL
- Pennell, CE
- Chatzi, L
- Estivill, X
- Holloway, JW
- Boomsma, DI
- Montgomery, GW
- Murabito, JM
- Spector, TD
- Power, C
- Järvelin, M-R
- Bisgaard, H
- Grant, SF
- Sørensen, TI
- Jaddoe, VW
- Jacobsson, B
- Melbye, M
- McCarthy, MI
- Hattersley, AT
- Hayes, MG
- Frayling, TM
- Hivert, M-F
- Felix, JF
- Hyppönen, E
- Lowe, WL
- Evans, DM
- Lawlor, DA
- Feenstra, B
- Freathy, RM
DOIAbstract
Genome-wide association studies (GWAS) of birth weight have focused on fetal genetics, while relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86,577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother-child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring...
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