A common variant associated with prostate cancer in European and African populations.
- Amundadottir, LT
- Sulem, P
- Gudmundsson, J
- Helgason, A
- Baker, A
- Agnarsson, BA
- Sigurdsson, A
- Benediktsdottir, KR
- Cazier, JB
- Sainz, J
- Jakobsdottir, M
- Kostic, J
- Magnusdottir, DN
- Ghosh, S
- Agnarsson, K
- Birgisdottir, B
- Le Roux, L
- Olafsdottir, A
- Blondal, T
- Andresdottir, M
- Gretarsdottir, OS
- Bergthorsson, JT
- Gudbjartsson, D
- Gylfason, A
- Thorleifsson, G
- Manolescu, A
- Kristjansson, K
- Geirsson, G
- Isaksson, H
- Douglas, J
- Johansson, JE
- Bälter, K
- Wiklund, F
- Montie, JE
- Yu, X
- Suarez, BK
- Ober, C
- Cooney, KA
- Gronberg, H
- Catalona, WJ
- Einarsson, GV
- Barkardottir, RB
- Gulcher, JR
- Kong, A
- Thorsteinsdottir, U
- Stefansson, K
DOIAbstract
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of af...
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