The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. Here, we report that a soluble form of CD4 failed to bind detectably to pMHC II in surface plasmon resonance-based assays, establishing a new upper limit for the solution affinity at 2.5 mM. However, when presented multivalently on magnetic beads, soluble CD4 bound pMHC II-expressing B cells, confirming that it is active and allowing mapping of the native coreceptor binding site on pMHC II. Whereas binding was undetectable in solution, the affinity of the CD4/pMHC II interac...
CD4(+) T cells convert the time that T cell receptors (TCRs) interact with peptides embedded within ...
T cell recognition is initiated by the binding of TCRs to peptide-MHCs (pMHCs), the interaction bein...
T cell antigen recognition requires binding of the T cell receptor (TCR) to a complex between peptid...
The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and ...
The αβ T-cell co-receptor CD4 enhances immune responses more than one million-fold in some assays, a...
T lymphocytes recognize peptides presented in the context of major histocompatibility complex (MHC) ...
T cells expressing CD4 recognize antigens presented by class II following the contact of CD4 with no...
The affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) presen...
he affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) present...
The T-cell differentiation antigen, CD4, is expressed by major histocompatibility (MHC) class II res...
SummaryWe have developed a single-molecule imaging technique that uses quantum-dot-labeled peptide-m...
The T cell coreceptors CD8 and CD4 bind to invariable regions of peptide-MHC class I (pMHCI) and cla...
The T cell coreceptors CD8 and CD4 bind to invariable regions of peptide-MHC class I (pMHCI) and cla...
Interaction of CD4 with MHC class II molecules plays a crucial role during thymic development and ac...
The T cell antigen receptor (TCR) and its ligand peptide-major histocompatibility complex (MHC) are ...
CD4(+) T cells convert the time that T cell receptors (TCRs) interact with peptides embedded within ...
T cell recognition is initiated by the binding of TCRs to peptide-MHCs (pMHCs), the interaction bein...
T cell antigen recognition requires binding of the T cell receptor (TCR) to a complex between peptid...
The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and ...
The αβ T-cell co-receptor CD4 enhances immune responses more than one million-fold in some assays, a...
T lymphocytes recognize peptides presented in the context of major histocompatibility complex (MHC) ...
T cells expressing CD4 recognize antigens presented by class II following the contact of CD4 with no...
The affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) presen...
he affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) present...
The T-cell differentiation antigen, CD4, is expressed by major histocompatibility (MHC) class II res...
SummaryWe have developed a single-molecule imaging technique that uses quantum-dot-labeled peptide-m...
The T cell coreceptors CD8 and CD4 bind to invariable regions of peptide-MHC class I (pMHCI) and cla...
The T cell coreceptors CD8 and CD4 bind to invariable regions of peptide-MHC class I (pMHCI) and cla...
Interaction of CD4 with MHC class II molecules plays a crucial role during thymic development and ac...
The T cell antigen receptor (TCR) and its ligand peptide-major histocompatibility complex (MHC) are ...
CD4(+) T cells convert the time that T cell receptors (TCRs) interact with peptides embedded within ...
T cell recognition is initiated by the binding of TCRs to peptide-MHCs (pMHCs), the interaction bein...
T cell antigen recognition requires binding of the T cell receptor (TCR) to a complex between peptid...