Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs22928...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We condu...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countri...
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countri...
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To i...
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We condu...
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To i...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We condu...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countri...
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countri...
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To i...
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We condu...
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To i...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We condu...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...