Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?
- Heid, IM
- Huth, C
- Loos, RJ
- Kronenberg, F
- Adamkova, V
- Anand, SS
- Ardlie, K
- Biebermann, H
- Bjerregaard, P
- Boeing, H
- Bouchard, C
- Ciullo, M
- Cooper, JA
- Corella, D
- Dina, C
- Engert, JC
- Fisher, E
- Francès, F
- Froguel, P
- Hebebrand, J
- Hegele, RA
- Hinney, A
- Hoehe, MR
- Hu, FB
- Hubacek, JA
- Humphries, SE
- Hunt, SC
- Illig, T
- Järvelin, MR
- Kaakinen, M
- Kollerits, B
- Krude, H
- Kumar, J
- Lange, LA
- Langer, B
- Li, S
- Luchner, A
- Lyon, HN
- Meyre, D
- Mohlke, KL
- Mooser, V
- Nebel, A
- Nguyen, TT
- Paulweber, B
- Perusse, L
- Qi, L
- Rankinen, T
- Rosskopf, D
- Schreiber, S
- Sengupta, S
- Sorice, R
- Suk, A
- Thorleifsson, G
- Thorsteinsdottir, U
- Völzke, H
- Vimaleswaran, KS
- Wareham, NJ
- Waterworth, D
- Yusuf, S
- Lindgren, C
- McCarthy, MI
- Lange, C
- Hirschhorn, JN
- Laird, N
- Wichmann, HE
DOIAbstract
The INSIG2 rs7566605 polymorphism was identified for obesity (BMI> or =30 kg/m(2)) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34 studies (n = 74,345), including general population (GP) studies, population-based studies with subjects selected for conditions related to a better health status ('healthy population', HP), and obesity studies (OB). We tested five hypotheses to explore potential sources of heterogeneity. The meta-analysis of 27 studies on Caucasian adults (n = 66,213) combining the different study designs did not support overall association of the CC-genotype with obesity, yielding an odds ratio (OR) of 1.05 (p-value = 0.27). The I(2) measure of 41% (p-valu...
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