The delineation of the beta-globin locus control region has led to a new understanding of the developmental regulation of the beta-globin gene cluster. It now seems that globin gene switching is effected through the sequential and mutually exclusive interaction of the locus control region with the embryonic, fetal and adult stage specific globin genes
During development, the α- and β-globin genes exhibit a highly conserved pattern of expression, givi...
Human haemoglobin is made up of two types of proteins called alpha and beta-globin. The β-Globin loc...
At present, the molecular mechanisms by which stem cells commit to and differentiate towards specifi...
The mammalian beta-globin locus is a multigene locus containing several globin genes and a number of...
We have used transgenic mice to study the influence of position of the human globin genes relative t...
The mammalian beta-globin locus is a multigene locus containing several globin genes and a number of...
The human globin locus consists of an upstream LCR and functional genes arranged sequentially in teh...
To investigate the control of the -globin gene during development, we produced transgenic mice in wh...
Different genes in the beta-like globin locus are expressed at specific times during development, Th...
The a- and b-globin gene clusters are subject to several levels of regulation. They are expressed e...
Thesis (M.S.)--University of Kansas, Biochemistry and Molecular Biology, 2007.The human β-globin loc...
We have examined the pattern of human globin gene switch- without (¸1%). Reversion to the rapid swit...
The globin chain synthetic pattern and the extent of DNA methylation within embryonic, fetal, and ad...
textabstractThe beta-globin locus control region (LCR) is contained on a 20 kb DNA fragmen...
SummaryDistal enhancers commonly contact target promoters via chromatin looping. In erythroid cells,...
During development, the α- and β-globin genes exhibit a highly conserved pattern of expression, givi...
Human haemoglobin is made up of two types of proteins called alpha and beta-globin. The β-Globin loc...
At present, the molecular mechanisms by which stem cells commit to and differentiate towards specifi...
The mammalian beta-globin locus is a multigene locus containing several globin genes and a number of...
We have used transgenic mice to study the influence of position of the human globin genes relative t...
The mammalian beta-globin locus is a multigene locus containing several globin genes and a number of...
The human globin locus consists of an upstream LCR and functional genes arranged sequentially in teh...
To investigate the control of the -globin gene during development, we produced transgenic mice in wh...
Different genes in the beta-like globin locus are expressed at specific times during development, Th...
The a- and b-globin gene clusters are subject to several levels of regulation. They are expressed e...
Thesis (M.S.)--University of Kansas, Biochemistry and Molecular Biology, 2007.The human β-globin loc...
We have examined the pattern of human globin gene switch- without (¸1%). Reversion to the rapid swit...
The globin chain synthetic pattern and the extent of DNA methylation within embryonic, fetal, and ad...
textabstractThe beta-globin locus control region (LCR) is contained on a 20 kb DNA fragmen...
SummaryDistal enhancers commonly contact target promoters via chromatin looping. In erythroid cells,...
During development, the α- and β-globin genes exhibit a highly conserved pattern of expression, givi...
Human haemoglobin is made up of two types of proteins called alpha and beta-globin. The β-Globin loc...
At present, the molecular mechanisms by which stem cells commit to and differentiate towards specifi...
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