Anthropometric factors and endometrial cancer risk: A systematic review and dose-response meta-analysis of prospective studies

Background: Greater body mass index has been convincingly related to increased endometrial cancer risk, however, whether adiposity earlier in life or abdominal fatness, is an independent risk factor and whether weight gain or greater height increases the risk is not clear. Methods: As part of the Continuous Update Project of the World Cancer Research Fund International we conducted a systematic review and metaanalysis of prospective studies of the association between anthropometric measures and endometrial cancer risk and searched PubMed and several other databases up to February 2015. Summary relative risks were calculated using a random effects model. Results: Thirty prospective studies of BMI and endometrial cancer risk with 22320 cases among 6445402 participants were included. The summary relative risk (RR) for a 5 unit increment was 1.54 (95% CI: 1.47-1.61, I2=81%). Although the test for nonlinearity was significant, pnonlinearity