Population pharmacokinetic properties of Piperaquine in Falciparum Malaria: an individual participant data-level meta-analysis
- Hoglund, RM
- Workman, L
- Edstein, MD
- Thanh, NX
- Quang, NN
- Zongo, I
- Ouedraogo, JB
- Borrmann, S
- Mwai, L
- Nsanzabana, C
- Price, RN
- Dahal, P
- Nosten, F
- Ashley, EA
- Phyo, AA
- Lwin, KM
- McGready, R
- Day, N
- Guerin, PJ
- White, NJ
- Barnes, KI
- Tarning, J
DOIAbstract
Background: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated P.falciparum malaria, but ACT resistance is spreading across Southeast Asia. Dihydroartemisinin-piperaquine is one of the five ACTs currently recommended by the World Health Organization. Previous studies suggest that young children (<5 years) with malaria are under-dosed. The aim of the following study utilised a population-based pharmacokinetic approach to optimise the antimalarial treatment regimen of piperaquine. Methods and Findings: Published pharmacokinetic studies on piperaquine were identified through a systematic literature review of articles published between January 1960 and February 2013. Individual plasma pipe...
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