The classification and alignment of multiple three-dimensional protein structures is a powerful way to detect similarities that cannot be discovered from the sequences alone and can help to infer phylogeny. However, the alignment process remains problematic for divergent structures. We have devised a fully automatic pipeline, HSF, drawing its inspiration from well-known structural alignment methods, which given a list of structures not only aligns all pairs but also classifies them fully. We demonstrate proof of principle for the new method by aligning the currently available set of highly diverged virus coat protein structures containing double β-barrels, as well as validating the method with established test sets for multiple structural a...
International audienceComparison of multiple protein structures has a broad range of applications in...
The basic operation in analysis of protein evolution is alignment: the specification of residue-resi...
International audienceComparison of multiple protein structures has a broad range of applications in...
The classification and alignment of multiple three-dimensional protein structures is a powerful way ...
Structural biologists will perform a significant portion of their future work in silico due to incre...
Structural biologists will perform a significant portion of their future work in silico due to incre...
Proteins are very complex physical objects consisting of thousands of atoms and hundreds of amino ac...
Comparison of multiple protein structures has a broad range of applications in the analysis of prote...
Proteins are very complex physical objects consisting of thousands of atoms and hundreds of amino ac...
Comparison of multiple protein structures has a broad range of applications in the analysis of prote...
Structural genomics aims to experimentally determine nearly all protein folds by 2010, which makes ...
Structural genomics aims to experimentally determine nearly all protein folds by 2010, which makes ...
An algorithm is presented for the accurate and rapid generation of multiple protein sequence alignme...
An algorithm is presented for the accurate and rapid generation of multiple protein sequence alignme...
An algorithm is presented for the accurate and rapid generation of multiple protein sequence alignme...
International audienceComparison of multiple protein structures has a broad range of applications in...
The basic operation in analysis of protein evolution is alignment: the specification of residue-resi...
International audienceComparison of multiple protein structures has a broad range of applications in...
The classification and alignment of multiple three-dimensional protein structures is a powerful way ...
Structural biologists will perform a significant portion of their future work in silico due to incre...
Structural biologists will perform a significant portion of their future work in silico due to incre...
Proteins are very complex physical objects consisting of thousands of atoms and hundreds of amino ac...
Comparison of multiple protein structures has a broad range of applications in the analysis of prote...
Proteins are very complex physical objects consisting of thousands of atoms and hundreds of amino ac...
Comparison of multiple protein structures has a broad range of applications in the analysis of prote...
Structural genomics aims to experimentally determine nearly all protein folds by 2010, which makes ...
Structural genomics aims to experimentally determine nearly all protein folds by 2010, which makes ...
An algorithm is presented for the accurate and rapid generation of multiple protein sequence alignme...
An algorithm is presented for the accurate and rapid generation of multiple protein sequence alignme...
An algorithm is presented for the accurate and rapid generation of multiple protein sequence alignme...
International audienceComparison of multiple protein structures has a broad range of applications in...
The basic operation in analysis of protein evolution is alignment: the specification of residue-resi...
International audienceComparison of multiple protein structures has a broad range of applications in...