Vitamin D insufficiency in the first 6 months of infancy and challenge‐proven IgE‐mediated food allergy at 1 year of age: a case‐cohort study
- Molloy, J
- Koplin, JJ
- Allen, KJ
- Tang, MLK
- Collier, F
- Carlin, JB
- Saffery, R
- Burgner, D
- Ranganathan, S
- Dwyer, T
- Ward, AC
- Moreno-Betancur, M
- Clarke, M
- Ponsonby, AL
- Vuillermin, P
DOIAbstract
Background Ecological evidence suggests vitamin D insufficiency (VDI) due to lower ambient ultraviolet radiation (UVR) exposure may be a risk factor for IgE‐mediated food allergy. However, there are no studies relating directly measured VDI during early infancy to subsequent challenge‐proven food allergy. Objective To prospectively investigate the association between VDI during infancy and challenge‐proven food allergy at 1 year. Methods In a birth cohort (n = 1074), we used a case‐cohort design to compare 25‐hydroxyvitamin D3 (25(OH)D3) levels among infants with food allergy vs a random subcohort (n = 274). The primary exposures were VDI (25(OH)D3 <50 nM) at birth and 6 months of age. Ambient UVR and time in the sun were combined to esti...
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