Add to ORKGWe have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation
Over the last 10 years, structural studies of the ligand-binding domains of nuclear hormone receptor...
AbstractBackground: Estrogens exert their effects on target tissues by binding to a nuclear transcri...
AbstractLigand-dependent activation of transcription by nuclear receptors (NRs) is mediated by inter...
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a ...
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a ...
Here we summarise the results that have emerged from our structural studies on the oestrogen recepto...
Here we summarise the results that have emerged from our structural studies on the oestrogen recepto...
We have determined the three-dimensional structures of both alpha- and beta-forms of the ligand-bind...
Here we review the results that have emerged from our structural studies on the oestrogen receptor l...
AbstractBackground: Estrogens exert their effects on target tissues by binding to a nuclear transcri...
Background: Estrogens exert their effects on target tissues by binding to a nuclear transcription fa...
The steroid hormone receptors are characterized by binding to relatively rigid, inflexible endogenou...
BACKGROUND: Estrogens exert their effects on target tissues by binding to a nuclear transcription fa...
BACKGROUND: Estrogens exert their effects on target tissues by binding to a nuclear transcription fa...
Over the last 10 years, structural studies of the ligand-binding domains of nuclear hormone receptor...
Over the last 10 years, structural studies of the ligand-binding domains of nuclear hormone receptor...
AbstractBackground: Estrogens exert their effects on target tissues by binding to a nuclear transcri...
AbstractLigand-dependent activation of transcription by nuclear receptors (NRs) is mediated by inter...
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a ...
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a ...
Here we summarise the results that have emerged from our structural studies on the oestrogen recepto...
Here we summarise the results that have emerged from our structural studies on the oestrogen recepto...
We have determined the three-dimensional structures of both alpha- and beta-forms of the ligand-bind...
Here we review the results that have emerged from our structural studies on the oestrogen receptor l...
AbstractBackground: Estrogens exert their effects on target tissues by binding to a nuclear transcri...
Background: Estrogens exert their effects on target tissues by binding to a nuclear transcription fa...
The steroid hormone receptors are characterized by binding to relatively rigid, inflexible endogenou...
BACKGROUND: Estrogens exert their effects on target tissues by binding to a nuclear transcription fa...
BACKGROUND: Estrogens exert their effects on target tissues by binding to a nuclear transcription fa...
Over the last 10 years, structural studies of the ligand-binding domains of nuclear hormone receptor...
Over the last 10 years, structural studies of the ligand-binding domains of nuclear hormone receptor...
AbstractBackground: Estrogens exert their effects on target tissues by binding to a nuclear transcri...
AbstractLigand-dependent activation of transcription by nuclear receptors (NRs) is mediated by inter...