The house dust mite is the principal source of perennial aeroallergens in man. How these allergens activate innate and adaptive immunity is unclear, and therefore, there are no therapies targeting mite allergens. Here, we show that house dust mite extract activates store-operated Ca2+ channels, a common signaling module in numerous cell types in the lung. Activation of channel pore-forming Orai1 subunits by mite extract requires gating by STIM1 proteins. Although mite extract stimulates both protease-activated receptor type 2 (PAR2) and PAR4 receptors, Ca2+ influx is more tightly coupled to the PAR4 pathway. We identify a major role for the serine protease allergen Der p3 in stimulating Orai1 channels and show that a therapy involving sub-m...
Protease-activated receptor-2 (PAR-2) is known to be involved in epidermal permeability barrier func...
Asthma is a chronic life-threatening disease of worldwide importance. Although allergic asthma and r...
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching an...
The house dust mite is the principal source of perennial aeroallergens in man. How these allergens a...
Abstract House dust mite allergens (HDM) cause bronchoconstriction in asthma patients and induce an ...
The airway epithelium plays a critical role in innate responses to airborne allergens by secreting I...
Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous subst...
Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous subst...
The airway epithelium forms the first barrier against aeroallergens, including house dust mite (HDM)...
Adequate fluid secretion from airway mucosa is essential for maintaining mucociliary clearance, and ...
Throughout many parts of the world house dust mites (HDM) are considered as a major source of indoor...
BACKGROUND: The submucosal gland (SMG) is important in the control of airway surface fluid. Protease...
House dust mites are an unsurpassed cause of atopic sensitization and allergic illness throughout th...
We investigated and compared the mechanisms by which two dust mite proteolytic allergens, Der p 1 an...
Serodominant group 1 allergens of house dust mites (HDMs) are cysteine protease digestive enzymes. B...
Protease-activated receptor-2 (PAR-2) is known to be involved in epidermal permeability barrier func...
Asthma is a chronic life-threatening disease of worldwide importance. Although allergic asthma and r...
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching an...
The house dust mite is the principal source of perennial aeroallergens in man. How these allergens a...
Abstract House dust mite allergens (HDM) cause bronchoconstriction in asthma patients and induce an ...
The airway epithelium plays a critical role in innate responses to airborne allergens by secreting I...
Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous subst...
Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous subst...
The airway epithelium forms the first barrier against aeroallergens, including house dust mite (HDM)...
Adequate fluid secretion from airway mucosa is essential for maintaining mucociliary clearance, and ...
Throughout many parts of the world house dust mites (HDM) are considered as a major source of indoor...
BACKGROUND: The submucosal gland (SMG) is important in the control of airway surface fluid. Protease...
House dust mites are an unsurpassed cause of atopic sensitization and allergic illness throughout th...
We investigated and compared the mechanisms by which two dust mite proteolytic allergens, Der p 1 an...
Serodominant group 1 allergens of house dust mites (HDMs) are cysteine protease digestive enzymes. B...
Protease-activated receptor-2 (PAR-2) is known to be involved in epidermal permeability barrier func...
Asthma is a chronic life-threatening disease of worldwide importance. Although allergic asthma and r...
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching an...