Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of corticotrophin-releasing hormone (CRH) in vitro, the response being antagonized by the cyclo-oxygenase inhibitor, indomethacin. The effects of cytokines on the other major ACTH-releasing hormone, vasopressin (AVP), and the other neurohypophysial hormone, oxytocin, have been little studied, and the published data are conflicting. We have therefore used a previously validated rat hypothalamic explant model to evaluate whether IL-1 beta and IL-6 can directly activate the AVP and oxytocin neurosecretory system. In addition, we have also investigated the effects of inhibition of cyclo-oxygenase (CO) and lipoxygenase (LO) activities on the stimulated rele...
Interleukin 1b (IL-1b) stimulates the hypothalamic- pituitary-adrenal axis, however the autoparacrin...
The present work shows that the corticotropin-releasing factor (CRF)-releasing activity of interleuk...
While interleukin-1 (IL-1) is intimately involved in locally modulating the acute inflammatory respo...
Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of cortico...
Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of cortico...
It has previously been shown that interleukin-1 (IL-1) directly stimulates the release of CRH-41 fro...
Antigen-activated immune cells acutely release cytokines which, besides their effects on the immune ...
It has previously been shown that the cytokines interleukin-1 beta and interleukin-6 (IL-1 beta and ...
There is clear evidence for communication between the immune and neuroendocrine systems. However, th...
While interleukin-1 (IL-1), a monocyte-derived polypeptide, clearly stimulates the hypothalamo-pitui...
Both constitutive and inducible interleukin-1 (IL-1) gene expressions have been described in the cen...
The cytokine interleukin-6 (IL-6) is produced by a variety of cells, including macrophages, T-cells,...
Bacterial lipopolysaccharide (LPS) and prostaglandins (PG) E2 and F2 alpha are putative activators o...
Systemic administration of the cytokine IL-1β produces a significant release of ACTH into the plasma...
Bacterial lipopolysaccharide (LPS) and prostaglandins (PG) E2 and F2 alpha are putative activators o...
Interleukin 1b (IL-1b) stimulates the hypothalamic- pituitary-adrenal axis, however the autoparacrin...
The present work shows that the corticotropin-releasing factor (CRF)-releasing activity of interleuk...
While interleukin-1 (IL-1) is intimately involved in locally modulating the acute inflammatory respo...
Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of cortico...
Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of cortico...
It has previously been shown that interleukin-1 (IL-1) directly stimulates the release of CRH-41 fro...
Antigen-activated immune cells acutely release cytokines which, besides their effects on the immune ...
It has previously been shown that the cytokines interleukin-1 beta and interleukin-6 (IL-1 beta and ...
There is clear evidence for communication between the immune and neuroendocrine systems. However, th...
While interleukin-1 (IL-1), a monocyte-derived polypeptide, clearly stimulates the hypothalamo-pitui...
Both constitutive and inducible interleukin-1 (IL-1) gene expressions have been described in the cen...
The cytokine interleukin-6 (IL-6) is produced by a variety of cells, including macrophages, T-cells,...
Bacterial lipopolysaccharide (LPS) and prostaglandins (PG) E2 and F2 alpha are putative activators o...
Systemic administration of the cytokine IL-1β produces a significant release of ACTH into the plasma...
Bacterial lipopolysaccharide (LPS) and prostaglandins (PG) E2 and F2 alpha are putative activators o...
Interleukin 1b (IL-1b) stimulates the hypothalamic- pituitary-adrenal axis, however the autoparacrin...
The present work shows that the corticotropin-releasing factor (CRF)-releasing activity of interleuk...
While interleukin-1 (IL-1) is intimately involved in locally modulating the acute inflammatory respo...