Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration of the glycolipid ligand alpha-galactosylceramide (alpha-GalCer) or the sphingosine-truncated alpha-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and gamma interferons that contribute to DC maturation. This process enhances T cell immunity to antigens presented by the DC. The adjuvant activity is further amplified if APCs are stimulated through Toll-like receptor 4, suggesting that iNKT cell signals can amplify maturation induced by microbial stimuli. The adjuvant activity of alpha-GalCer enhances both priming and boosting of CD8(+) T cells to coadministered peptide or protein antigens, inclu...
CD1d-restricted natural killer T cells with invariant T cell receptor alpha chains (iNKT cells) are ...
CD1d-restricted invariant NKT (iNKT) cells can enhance immunity to cancer or prevent autoimmunity, d...
International audienceImmunotherapy aiming at enhancing innate and acquired host immunity is a promi...
Activation of invariant CD1d-dependent NKT cells (iNKT cells) in vivo through administration of the ...
Modification in the function of dendritic cells (DC), such as that achieved by microbial stimuli or ...
Activation of invariant NK T (iNKT) cells with the glycolipid alpha-galactosylceramide promotes CD8(...
CD1d-restricted invariant natural killer T (iNKT) cells are considered an attractive target for canc...
Invariant NKT (iNKT) cells are potent activators of DCs, NK cells, and T cells, and their antitumor ...
CD1d-restricted invariant natural killer T cells (iNKT cells) mediate strong antitumor immunity when...
Invariant natural killer (iNKT) cells are a small subset of innate cells which express an invariant...
BACKGROUND: Therapeutic cancer vaccines aim to boost the natural immunity against transformed cancer...
a-galactosylceramide (a-GalCer) is the prototypical lipid ligand for invariant NKT cells. Recent stu...
Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, non...
Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid α-galactosylceramide (α...
α-Galactosylceramide (α-GalCer) is the prototypical lipid ligand for invariant NKT cells. Recent stu...
CD1d-restricted natural killer T cells with invariant T cell receptor alpha chains (iNKT cells) are ...
CD1d-restricted invariant NKT (iNKT) cells can enhance immunity to cancer or prevent autoimmunity, d...
International audienceImmunotherapy aiming at enhancing innate and acquired host immunity is a promi...
Activation of invariant CD1d-dependent NKT cells (iNKT cells) in vivo through administration of the ...
Modification in the function of dendritic cells (DC), such as that achieved by microbial stimuli or ...
Activation of invariant NK T (iNKT) cells with the glycolipid alpha-galactosylceramide promotes CD8(...
CD1d-restricted invariant natural killer T (iNKT) cells are considered an attractive target for canc...
Invariant NKT (iNKT) cells are potent activators of DCs, NK cells, and T cells, and their antitumor ...
CD1d-restricted invariant natural killer T cells (iNKT cells) mediate strong antitumor immunity when...
Invariant natural killer (iNKT) cells are a small subset of innate cells which express an invariant...
BACKGROUND: Therapeutic cancer vaccines aim to boost the natural immunity against transformed cancer...
a-galactosylceramide (a-GalCer) is the prototypical lipid ligand for invariant NKT cells. Recent stu...
Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, non...
Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid α-galactosylceramide (α...
α-Galactosylceramide (α-GalCer) is the prototypical lipid ligand for invariant NKT cells. Recent stu...
CD1d-restricted natural killer T cells with invariant T cell receptor alpha chains (iNKT cells) are ...
CD1d-restricted invariant NKT (iNKT) cells can enhance immunity to cancer or prevent autoimmunity, d...
International audienceImmunotherapy aiming at enhancing innate and acquired host immunity is a promi...