Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus.
- Lee, JM
- Shirodaria, C
- Jackson, CE
- Robson, MD
- Antoniades, C
- Francis, JM
- Wiesmann, F
- Channon, KM
- Neubauer, S
- Choudhury, RP
DOIAbstract
Vascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flow-mediated dilatation (FMD). Patients with diabetes showed lower aortic distensibility (2.1 x 10(-3) vs . 3.5 x 10(-3) mmHg-1, p<0.01), faster PWV (8.8 vs ., 6.2 m/s, p<0.01) and impaired FMD (8.5% vs . 13.8%, p<0.05). Diabetes was an independent negative predictor of distensibility. Aortic atherosclerosis was similar in the two groups. There was a negative correlation between aortic distensibility and atherosclerosis in control subjects only, su...
Add to ORKG