The ecto-5'-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive cells and endothelial cells. It works in conjunction with CD39 to regulate the formation and degradation of adenosine in vivo. Adenosine has previously been shown to suppress the proliferation and cytokine secretion of T-cells and recent evidence suggests that inhibition of CD73 has the potential to enhance T-cell directed therapies. Here we utilised a CD73 knockout mouse model to assess the suppressive ability of CD73 on CD8+ T-cell classical memory and memory “inflation”, induced by murine cytomegalovirus (MCMV) infection and adenovirus immunisation. We show that CD73 is dispensable for normal CD8+ T-cell differentiation and function in both models...
CD73 is a cell-surface enzyme that suppresses immune responses by producing extracellular adenosine....
Synthesis of extracellular adenosine by the ectonucleotidases CD39 and CD73 represents an important ...
Extracellular adenosine 5'-triphosphate (ATP) acts on many immune cells to promote inflammation. Con...
<div><p>The ecto-5'-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive ...
The ecto-5’-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive cells an...
Artículo de publicación ISIExtracellular ATP is a danger signal released by dying and damaged cells,...
Artículo de publicación ISIThe CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, ...
The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor...
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface marke...
CD73 functions as an ecto-5'-nucleotidase to produce extracellular adenosine that has anti-inflammat...
After an inflammatory stimulus, lymphocyte migration into draining lymph nodes increases dramaticall...
AbstractExtracellular ATP is a danger signal released by dying and damaged cells, and it functions a...
CD73 functions as an ecto-59-nucleotidase to produce extracellular adenosine that has anti-inflammat...
Tumors use several strategies to evade immunosurveillance. One such mechanism is the generation of a...
<p>CD73<sup>−/−</sup> and C57BL/6 mice were immunised intravenously (i.v) with 1×10<sup>9</sup> pfu ...
CD73 is a cell-surface enzyme that suppresses immune responses by producing extracellular adenosine....
Synthesis of extracellular adenosine by the ectonucleotidases CD39 and CD73 represents an important ...
Extracellular adenosine 5'-triphosphate (ATP) acts on many immune cells to promote inflammation. Con...
<div><p>The ecto-5'-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive ...
The ecto-5’-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive cells an...
Artículo de publicación ISIExtracellular ATP is a danger signal released by dying and damaged cells,...
Artículo de publicación ISIThe CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, ...
The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor...
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface marke...
CD73 functions as an ecto-5'-nucleotidase to produce extracellular adenosine that has anti-inflammat...
After an inflammatory stimulus, lymphocyte migration into draining lymph nodes increases dramaticall...
AbstractExtracellular ATP is a danger signal released by dying and damaged cells, and it functions a...
CD73 functions as an ecto-59-nucleotidase to produce extracellular adenosine that has anti-inflammat...
Tumors use several strategies to evade immunosurveillance. One such mechanism is the generation of a...
<p>CD73<sup>−/−</sup> and C57BL/6 mice were immunised intravenously (i.v) with 1×10<sup>9</sup> pfu ...
CD73 is a cell-surface enzyme that suppresses immune responses by producing extracellular adenosine....
Synthesis of extracellular adenosine by the ectonucleotidases CD39 and CD73 represents an important ...
Extracellular adenosine 5'-triphosphate (ATP) acts on many immune cells to promote inflammation. Con...