(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clinically as a PET agent both for delineation of tumor hypoxia and as an effective indicator of patient prognosis, but there are still aspects of the mechanism of action that are not fully understood.The retention of radioactivity in tumors after administration of (64)Cu-ATSM in vivo is substantially higher for tumors with a significant hypoxic fraction. This hypoxia-dependent retention is believed to involve the reduction of Cu-ATSM, followed by the loss of copper to cellular copper processing. To shed light on a possible role of copper metabolism in hypoxia targeting, we have compared (64)Cu retention in vitro and in vivo in CaNT and EMT6 cells...
International audienceMapping tumor hypoxia is a great challenge in positron emission tomography (PE...
International audienceMapping tumor hypoxia is a great challenge in positron emission tomography (PE...
Hypoxia plays important roles in the prognosis of malignant brain tumors such as glioblastoma becaus...
(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clini...
(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clini...
Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid tumor environ...
We showed previously that, in vitro, copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) uptak...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
The development of hypoxia-selective radiopharmaceuticals for use as therapeutic and/or imaging agen...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
The development of hypoxia-selective radiopharmaceuticals for use as therapeutic and/or imaging agen...
International audienceMapping tumor hypoxia is a great challenge in positron emission tomography (PE...
International audienceMapping tumor hypoxia is a great challenge in positron emission tomography (PE...
Hypoxia plays important roles in the prognosis of malignant brain tumors such as glioblastoma becaus...
(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clini...
(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clini...
Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid tumor environ...
We showed previously that, in vitro, copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) uptak...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
The development of hypoxia-selective radiopharmaceuticals for use as therapeutic and/or imaging agen...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
CERVOXY/LDM TEPInternational audienceBackground: Diacetyl-bis(N4-methylthiosemicarbazone), labeled w...
The development of hypoxia-selective radiopharmaceuticals for use as therapeutic and/or imaging agen...
International audienceMapping tumor hypoxia is a great challenge in positron emission tomography (PE...
International audienceMapping tumor hypoxia is a great challenge in positron emission tomography (PE...
Hypoxia plays important roles in the prognosis of malignant brain tumors such as glioblastoma becaus...