Synthesis and utility of the 3,3-dimethyl-5-substituted-2-pyrrolidinone Quat' chiral auxiliary
- Davies, SG
- Dixon, DJ
- Doisneau, GJM
- Prodger, JC
- Sanganee, HJ
Publication date
April 2002
DOI Publisher
Elsevier BV Journal
Tetrahedron AsymmetryAbstract
The synthesis and utility of the 3,3-dimethyl-5-substituted-2-pyrrolidinone 'Quat' chiral auxiliary in stereoselective enolate reactions of attached N-acyl side chains combined with the mild and non-racemising conditions required for the ultimate removal of the chiral side chain is described. © 2002 Elsevier Science Ltd. All rights reserved
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