"Inappropriate" expression of class II major histocompatibility complex (MHC) molecules by target cells has been found in all organ-specific autoimmune diseases so far examined for the presence of this phenomenon. These glycoproteins may have a functional role as class II+ thyrocytes are able to present both small fragments of foreign antigens and autoantigens to helper T cells. Interferon gamma is a likely modulator of MHC class II expression in the thyroid but other signals like thyroid-stimulating hormone seem to influence its action. By contrast, it appears that lymphokines are not involved in inducing the inappropriate MHC class II expression observed in situ in the pancreatic beta cells of diabetics. These data suggest that regulation...
The spontaneous expression of Class II molecules (HLA-DR) was studied in cultured thyrocytes obtaine...
The expression of MHC class II molecules on (i-cells of the pancreatic islet has been proposed to pl...
The BB/Wor rat develops spontaneous autoimmune diabetes mellitus and also frequently develops lympho...
"Inappropriate" expression of class II major histocompatibility complex (MHC) molecules by target ce...
Endocrine epithelial cells do not normally express human leukocyte antigen (HLA) class II molecules,...
Inappropriate expression of HLA Class II (D/DR) molecules has been detected in the target cells of m...
Excessive HLA class II expression is found on the target tissues of the majority of human autoimmune...
The first step in the induction of immune responses, whether humoral or cell mediated, requires the ...
HLA class II molecules are surface glycoproteins which are essential in the initiation of immune res...
AbstractType 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing β-cells o...
It is well established that interactions between CD4(+) T cells and major histocompatibility complex...
Type 1 diabetes is characterized by T-cell–medi-ated destruction of insulin-producing -cells.The str...
In autoimmune thyroid disease, thyroid epithelial cells (TEC) express major histocompatibility compl...
Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes a...
In both thyroid autoimmune diseases Graves' and Hashimoto's thyroiditis, the epithelial thyroid foll...
The spontaneous expression of Class II molecules (HLA-DR) was studied in cultured thyrocytes obtaine...
The expression of MHC class II molecules on (i-cells of the pancreatic islet has been proposed to pl...
The BB/Wor rat develops spontaneous autoimmune diabetes mellitus and also frequently develops lympho...
"Inappropriate" expression of class II major histocompatibility complex (MHC) molecules by target ce...
Endocrine epithelial cells do not normally express human leukocyte antigen (HLA) class II molecules,...
Inappropriate expression of HLA Class II (D/DR) molecules has been detected in the target cells of m...
Excessive HLA class II expression is found on the target tissues of the majority of human autoimmune...
The first step in the induction of immune responses, whether humoral or cell mediated, requires the ...
HLA class II molecules are surface glycoproteins which are essential in the initiation of immune res...
AbstractType 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing β-cells o...
It is well established that interactions between CD4(+) T cells and major histocompatibility complex...
Type 1 diabetes is characterized by T-cell–medi-ated destruction of insulin-producing -cells.The str...
In autoimmune thyroid disease, thyroid epithelial cells (TEC) express major histocompatibility compl...
Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes a...
In both thyroid autoimmune diseases Graves' and Hashimoto's thyroiditis, the epithelial thyroid foll...
The spontaneous expression of Class II molecules (HLA-DR) was studied in cultured thyrocytes obtaine...
The expression of MHC class II molecules on (i-cells of the pancreatic islet has been proposed to pl...
The BB/Wor rat develops spontaneous autoimmune diabetes mellitus and also frequently develops lympho...