The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain unbundled microtubule filaments, suggesting that localized activation of microtubule-associated proteins (MAP) at the transition zone may bundle these filaments during axonal growth. Dephosphorylation is thought to lead to MAP activation, but specific molecular pathways have remained elusive. We find that Spinophilin, a Protein-phosphatase 1 (PP1) targeting protein, is responsible for the dephosphorylation of the MAP Doublecortin (Dcx) Ser 297 selectively at the "wrist" of growing axons, leading to activation. Loss of activity at the "wrist" is evident as an impaired microtubule cytoskeleton along the shaft. These findings suggest that spatiall...
Axon formation is a hallmark of initial neuronal polarization. This process is thought to be regulat...
© 2019 Maryam MoslehiX-linked Doublecortin (DCX) is a 40 kDa neuron-specific microtubule (MT)-associ...
Mechanisms underlying age-dependent changes of dendritic spines on striatal medium spiny neurons are...
SummaryThe axonal shafts of neurons contain bundled microtubules, whereas extending growth cones con...
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-ass...
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-ass...
Spinophilin is a protein phosphatase-1- and actin-binding protein that modulates excitatory synaptic...
Doublecortin (DCX) is a microtubule-associated protein required for neuronal migration to the cerebr...
Protein phosphatase-1 (PP1) plays an important role in a variety of cellular processes, including mu...
The development and plasticity of axons and dendrites in mammalian neurons may depend on the presenc...
Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory sy...
Microtubules and actin are two essential cytoskeletal networks in neurons, providing structural supp...
Neuronal process extension is dependent on the reorganisation of the cytoskeleton, in particular mic...
Mutations in the human Doublecortin (DCX) gene cause X-linked lissencephaly, a neuronal migration di...
Microtubule-associated proteins (MAPs) are main candidates to stabilize neuronal microtubules, playi...
Axon formation is a hallmark of initial neuronal polarization. This process is thought to be regulat...
© 2019 Maryam MoslehiX-linked Doublecortin (DCX) is a 40 kDa neuron-specific microtubule (MT)-associ...
Mechanisms underlying age-dependent changes of dendritic spines on striatal medium spiny neurons are...
SummaryThe axonal shafts of neurons contain bundled microtubules, whereas extending growth cones con...
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-ass...
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-ass...
Spinophilin is a protein phosphatase-1- and actin-binding protein that modulates excitatory synaptic...
Doublecortin (DCX) is a microtubule-associated protein required for neuronal migration to the cerebr...
Protein phosphatase-1 (PP1) plays an important role in a variety of cellular processes, including mu...
The development and plasticity of axons and dendrites in mammalian neurons may depend on the presenc...
Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory sy...
Microtubules and actin are two essential cytoskeletal networks in neurons, providing structural supp...
Neuronal process extension is dependent on the reorganisation of the cytoskeleton, in particular mic...
Mutations in the human Doublecortin (DCX) gene cause X-linked lissencephaly, a neuronal migration di...
Microtubule-associated proteins (MAPs) are main candidates to stabilize neuronal microtubules, playi...
Axon formation is a hallmark of initial neuronal polarization. This process is thought to be regulat...
© 2019 Maryam MoslehiX-linked Doublecortin (DCX) is a 40 kDa neuron-specific microtubule (MT)-associ...
Mechanisms underlying age-dependent changes of dendritic spines on striatal medium spiny neurons are...