Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

Jervis, PJ
Moulis, M
Jukes, J-P
Ghadbane, H
Cox, LR
Cerundolo, V
Besra, GS

Open link

Publication date

July 2012

DOI

10.1016/j.carres.2012.02.034

Publisher

Elsevier BV

Journal

Carbohydrate Research

Abstract

A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy- α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells. © 2012 Elsevier Ltd. All rights reserved

Extracted data

We use cookies to provide a better user experience.

Data Protection

Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

Abstract

Extracted data

Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

Abstract

Extracted data

Related items

Related items