The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition.
- Crowe, FL
- Key, TJ
- Allen, NE
- Appleby, PN
- Roddam, A
- Overvad, K
- Grønbaek, H
- Tjønneland, A
- Halkjaer, J
- Dossus, L
- Boeing, H
- Kröger, J
- Trichopoulou, A
- Dilis, V
- Trichopoulos, D
- Boutron-Ruault, MC
- De Lauzon, B
- Clavel-Chapelon, F
- Palli, D
- Berrino, F
- Panico, S
- Tumino, R
- Sacerdote, C
- Bueno-de-Mesquita, HB
- Vrieling, A
- van Gils, CH
- Peeters, PH
- Gram, IT
- Skeie, G
- Lund, E
- Rodríguez, L
- Jakszyn, P
- Molina-Montes, E
- Tormo, MJ
- Barricarte, A
- Larrañaga, N
- Khaw, KT
- Bingham, S
- Rinaldi, S
- Slimani, N
- Norat, T
- Gallo, V
- Riboli, E
- Kaaks, R
DOIAbstract
Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple line...
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