The new gene editing system CRISPR/Cas9, composed of a complex composed of a guide RNA and the Cas9 endonuclease, promises to revolutionize biological research and potentially allow clinicians to directly modify patient DNA in vivo. While its applications in the treatment of genetic diseases and in modifying immune cells for immunotherapy are currently being explored, CRISPR/Cas9’s potential utility as a modular system for targeting tumor-specific mutated sequences has not as of yet been explored. While CRISPR/Cas9 is specific enough to target small insertions and deletions or gross chromosomal rearrangements, it is not specific enough to reliably restrict editing to single nucleotide variants (SNVs), which compose the majority of cancer-as...
CRISPR/Cas9 has become a powerful method for making changes to the genome of many organisms. First d...
Cancer is considered by not only multiple genetic but also epigenetic amendments that drive malignan...
The cancer-modelling field is now experiencing a conversion with the recent emergence of the RNA-pr...
The new gene editing system CRISPR/Cas9, composed of a complex composed of a guide RNA and the Cas9 ...
Genome editing allows for the precise manipulation of DNA sequences in a cell making this technology...
With the expansion of the microbiology field of research, a new genome editing tool arises from the ...
In this review, we summarize CRISPR-Cas9 system-based gene modification for the therapeutic treatmen...
Abstract Genome editing allows for the precise manipulation of DNA sequences in a cell making this t...
The increasing burden on human malignant diseases became a major concern for healthcare practitioner...
The progress of genetic engineering in the 1970s brought about a paradigm shift in genome editing te...
The discovery of the bacterial Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR) a...
Gene editing, especially with clustered regularly interspaced short palindromic repeats associated p...
Cancer is the second leading cause of death globally and remains a major economic and social burden....
CRISPR is a revolutionary genome-editing technology derived from the adaptive immune system of proka...
Precise clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic and epig...
CRISPR/Cas9 has become a powerful method for making changes to the genome of many organisms. First d...
Cancer is considered by not only multiple genetic but also epigenetic amendments that drive malignan...
The cancer-modelling field is now experiencing a conversion with the recent emergence of the RNA-pr...
The new gene editing system CRISPR/Cas9, composed of a complex composed of a guide RNA and the Cas9 ...
Genome editing allows for the precise manipulation of DNA sequences in a cell making this technology...
With the expansion of the microbiology field of research, a new genome editing tool arises from the ...
In this review, we summarize CRISPR-Cas9 system-based gene modification for the therapeutic treatmen...
Abstract Genome editing allows for the precise manipulation of DNA sequences in a cell making this t...
The increasing burden on human malignant diseases became a major concern for healthcare practitioner...
The progress of genetic engineering in the 1970s brought about a paradigm shift in genome editing te...
The discovery of the bacterial Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR) a...
Gene editing, especially with clustered regularly interspaced short palindromic repeats associated p...
Cancer is the second leading cause of death globally and remains a major economic and social burden....
CRISPR is a revolutionary genome-editing technology derived from the adaptive immune system of proka...
Precise clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic and epig...
CRISPR/Cas9 has become a powerful method for making changes to the genome of many organisms. First d...
Cancer is considered by not only multiple genetic but also epigenetic amendments that drive malignan...
The cancer-modelling field is now experiencing a conversion with the recent emergence of the RNA-pr...