Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models

Microphysiological systems (MPS) are a promising solution, to bridge current gaps in the predictive power of existing techniques in industrial substance testing (i.e., pharmaceutical, chemical, cosmetic and tobacco industries), as they mimic human physiology in vitro. A variety of microfluidics-based MPS have recently been developed. They can be split into three groups: (i) single-organ or “organ-on-a-chip”, (ii) multi-organ, and (iii) “body-on-a-chip” systems.1 “Organ-on-a-chip” systems focus mainly on a realistic representation of an organ’s multicellular microarchitecture and functionality. Multi-organ systems with two or more organs focus on specific organ interaction and interplay