Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
- Bitter, Hans
- Orlando, Elena
- Marco, Ruella
- Jun, Xu
- David, Barrett
- Joseph, Fraietta
- Tyler , Reich
- David , Ambrose
- Michael, Klichinsky
- Olga, Shestova
- Prachi, Patel
- Irina, Kulikovskaya
- Farzana, Nazimuddin
- Vijay, Bhoj
- Shannon, Maude
- Bruce, Levine
- Christopher, Nobles
- Frederic, Bushman
- Regina, Young
- John, Scholler
- Saar, Gill
- Carl, June
- Stephan, Grupp
- Joseph, Melenhorst
- Simon, Lacey
Publication date
October 2018
DOI Publisher
Springer Science and Business Media LLCAbstract
We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19– leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufacturing, and its product bound in cis to the CD19 epitope on the surface of leukemic cells, masking it from recognition by and conferring resistance to CTL019
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