By means of a systematic approach, several candidate solvents were tested for their feasibility of replacing the reprotoxic DMF as solvent used in large scale manufacture of peptide by the Solid Phase Peptide Synthesis (SPPS) methodology. N-Butylpyrrolidone (NBP) was found to be a viable green alternative solvent to replace DMF, appropriate to all stages of the SPPS
Solid Phase Peptide Synthesis (SPPS) is a key technology for the production of pharmaceutical grade ...
Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase s...
In solid-phase peptide synthesis, dichloromethane is the predominant solvent used to incorporate the...
Solid-phase peptide synthesis (SPPS) is the method of choice for the preparation of peptides in both...
Solid phase peptide synthesis (SPPS) is a widely used technology for the production of peptides at l...
To replace dimethylformamide (DMF) in fluorenylmethoxycarbonyl (Fmoc) solid-phase peptide synthesis,...
In recent years, peptides have gained more success as therapeutic compounds. Nowadays, the preferred...
In last decades, peptide therapeutics received great attention over small-molecule medications, as t...
NBP has proved an excellent alternative solvent to the hazardous DMF for SPPS. Here we studied the ...
none12noThe investigation of new green biogenic pyrrolidinones as alternative solvents to N,N-dimeth...
The synthesis of peptides by amide bond formation between suitably protected amino acids is a fundam...
NBP has proved an excellent alternative solvent to the hazardous DMF for SPPS. Here we studied the i...
PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturi...
Peptides are gaining ground in the pharmaceutical arena, with a total of 22 approvals over the last ...
In recent years, the work of various research groups has allowed the substitution of the hazardous s...
Solid Phase Peptide Synthesis (SPPS) is a key technology for the production of pharmaceutical grade ...
Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase s...
In solid-phase peptide synthesis, dichloromethane is the predominant solvent used to incorporate the...
Solid-phase peptide synthesis (SPPS) is the method of choice for the preparation of peptides in both...
Solid phase peptide synthesis (SPPS) is a widely used technology for the production of peptides at l...
To replace dimethylformamide (DMF) in fluorenylmethoxycarbonyl (Fmoc) solid-phase peptide synthesis,...
In recent years, peptides have gained more success as therapeutic compounds. Nowadays, the preferred...
In last decades, peptide therapeutics received great attention over small-molecule medications, as t...
NBP has proved an excellent alternative solvent to the hazardous DMF for SPPS. Here we studied the ...
none12noThe investigation of new green biogenic pyrrolidinones as alternative solvents to N,N-dimeth...
The synthesis of peptides by amide bond formation between suitably protected amino acids is a fundam...
NBP has proved an excellent alternative solvent to the hazardous DMF for SPPS. Here we studied the i...
PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturi...
Peptides are gaining ground in the pharmaceutical arena, with a total of 22 approvals over the last ...
In recent years, the work of various research groups has allowed the substitution of the hazardous s...
Solid Phase Peptide Synthesis (SPPS) is a key technology for the production of pharmaceutical grade ...
Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase s...
In solid-phase peptide synthesis, dichloromethane is the predominant solvent used to incorporate the...
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