Regioselective nitration of 3-fluoro-2-substituted benzoic acids

  • Hurth, Konstanze
  • Jacquier, Sebastien
  • Lehmann, Hansjoerg
  • Wilcken, Rainer
Publication date
April 2015

Abstract

The preparation of a series of 3-fluoro-2-substituted-6-nitro benzoic acids is described. The partially excellent regioselectivities observed in the nitration step can be rationalized in most cases using Fukui indices of local nucleophilicity

Extracted data

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