A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions
- Gadd, MS
- Jacques, DA
- Nisevic, I
- Craig, VJ
- Kwan, AH
- Guss, JM
- Matthews, JM
Publication date
January 2013
DOI Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)Abstract
Background: A putative intramolecular interaction in the Islet 1 (Isl1) transcription factor inhibits DNA binding. Results: An intramolecular interaction between the LIM domains and LIM homeobox 3 (Lhx3)-binding domain in Isl1 was characterized. Conclusion: The intramolecular interaction within Isl1 is weak but specific. Significance: This interaction likely prevents unproductive binding in the absence of cofactor proteins. 2013 by The American Society for Biochemistry and Molecular Biology, In
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