To increase the probability of success in drug discovery, the concept of drug-like properties was introduced. Efficiency metrics that normalize potency against these properties could help reach drug-like space more efficiently. Potential reasons for the inefficient use of metrics and suboptimal decision making are discussed. © 2013 American Chemical Society
Over the past 15 years there have been extensive efforts to understand and reduce the high attrition...
This project aims to harness artificial intelligence and machine learning approaches to improve the ...
Target-based drug discovery is the dominant paradigm of drug discovery; however, a comprehensive eva...
Introduction: Ligand efficiency metrics are almost universally accepted as a valuable indicator of c...
The judicious application of ligand or binding efficiency metrics, which quantify the molecular prop...
A recent viewpoint article (Improving the plausibility of success with inefficient metrics. ACS Med....
During the past decade, decreasing the attrition rate of drug development candidates reaching the ma...
The concept of molar efficiency is introduced as a new metric to enable assessment of reaction effic...
The concept of molar efficiency is introduced as a new metric to enable assessment of reaction effic...
For several decades, the pharmaceutical industry has suffered due to major issues such as reductions...
Ligand efficiency is a widely used design parameter in drug discovery. It is calculated by scaling a...
Designing efficient and green approaches to complex molecules is a challenge faced by any organizati...
Drug discovery plays a critical role in today’s society for treating and preventing sickness and pos...
Pharmaceutical companies depend on patent protection to recuperate the high costs of research and de...
<div><p>A striking contrast runs through the last 60 years of biopharmaceutical discovery, research,...
Over the past 15 years there have been extensive efforts to understand and reduce the high attrition...
This project aims to harness artificial intelligence and machine learning approaches to improve the ...
Target-based drug discovery is the dominant paradigm of drug discovery; however, a comprehensive eva...
Introduction: Ligand efficiency metrics are almost universally accepted as a valuable indicator of c...
The judicious application of ligand or binding efficiency metrics, which quantify the molecular prop...
A recent viewpoint article (Improving the plausibility of success with inefficient metrics. ACS Med....
During the past decade, decreasing the attrition rate of drug development candidates reaching the ma...
The concept of molar efficiency is introduced as a new metric to enable assessment of reaction effic...
The concept of molar efficiency is introduced as a new metric to enable assessment of reaction effic...
For several decades, the pharmaceutical industry has suffered due to major issues such as reductions...
Ligand efficiency is a widely used design parameter in drug discovery. It is calculated by scaling a...
Designing efficient and green approaches to complex molecules is a challenge faced by any organizati...
Drug discovery plays a critical role in today’s society for treating and preventing sickness and pos...
Pharmaceutical companies depend on patent protection to recuperate the high costs of research and de...
<div><p>A striking contrast runs through the last 60 years of biopharmaceutical discovery, research,...
Over the past 15 years there have been extensive efforts to understand and reduce the high attrition...
This project aims to harness artificial intelligence and machine learning approaches to improve the ...
Target-based drug discovery is the dominant paradigm of drug discovery; however, a comprehensive eva...
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