Add to ORKGA series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics
A series of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives (Ia-Im and IIa-IIe) designed...
A series of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide (TTA) derivatives were synthe...
1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar a...
A novel oxindole was discovered as an HIV non-nucleoside reverse transcriptase inhibitor via HTS usi...
The heterocyclic indole structure has been shown to be one of the most promising scaffolds, offering...
New 1H,3H-oxazolo[3,4-a]benzimidazoles (OBZs) were synthesized as HIV-1 non-nucleoside reverse trans...
A set of new pyrimido[5,4-b]indole derivatives that are structurally related to some non-nucleoside ...
A series of novel benzimidazolones and their analogues, characterized by the presence of one or more...
Seven novel N-arylsulfonyl-3-(2-yl-ethanone)-6-methylindole derivatives 4a–f and 6 were readily synt...
A new tetrahydroindazolylbenzamide derivative has been synthesized, characterized, and evaluated as ...
Novel 3'-spiro nucleoside analogues of the potent human immunodeficiency virus type 1 (HIV-1) revers...
International audienceIn the current study, twenty-two compounds based upon 3-hydroxy-3-(2-oxo-2-phe...
A new tetrahydroindazolylbenzamide derivative has been synthesized, characterized, and evaluated as ...
Novel oxindole derivatives bearing substituted cyclopropane ring have been designed on the basis of ...
The synthesis, and anti HIV-1 activity, of new derivatives of 4-amino-1,2-oxathiole 2,2-dioxide (3, ...
A series of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives (Ia-Im and IIa-IIe) designed...
A series of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide (TTA) derivatives were synthe...
1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar a...
A novel oxindole was discovered as an HIV non-nucleoside reverse transcriptase inhibitor via HTS usi...
The heterocyclic indole structure has been shown to be one of the most promising scaffolds, offering...
New 1H,3H-oxazolo[3,4-a]benzimidazoles (OBZs) were synthesized as HIV-1 non-nucleoside reverse trans...
A set of new pyrimido[5,4-b]indole derivatives that are structurally related to some non-nucleoside ...
A series of novel benzimidazolones and their analogues, characterized by the presence of one or more...
Seven novel N-arylsulfonyl-3-(2-yl-ethanone)-6-methylindole derivatives 4a–f and 6 were readily synt...
A new tetrahydroindazolylbenzamide derivative has been synthesized, characterized, and evaluated as ...
Novel 3'-spiro nucleoside analogues of the potent human immunodeficiency virus type 1 (HIV-1) revers...
International audienceIn the current study, twenty-two compounds based upon 3-hydroxy-3-(2-oxo-2-phe...
A new tetrahydroindazolylbenzamide derivative has been synthesized, characterized, and evaluated as ...
Novel oxindole derivatives bearing substituted cyclopropane ring have been designed on the basis of ...
The synthesis, and anti HIV-1 activity, of new derivatives of 4-amino-1,2-oxathiole 2,2-dioxide (3, ...
A series of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives (Ia-Im and IIa-IIe) designed...
A series of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide (TTA) derivatives were synthe...
1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar a...