Add to ORKGThe Raf-MEK-ERK signaling pathway is critical for cell survival, growth, proliferation and tumorigenesis. Among the three isoforms of Raf protein kinases, in vitro and in vivo studies have shown that B-Raf functions as the primary MEK activator. B-Raf is one of the most frequently mutated genes in human cancers with a high prevalence in melanoma, and many of the B-Raf mutations activate the kinase activity of B-Raf. B-Raf kinase represents an excellent target for anticancer therapy based on preclinical target validation, epidemiology and drugability. Several small-molecule inhibitors of B-Raf kinase are currently undergoing clinical evaluation, with others due to enter clinical development in the near future
Background: The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signal...
The Raf/MEK/ERK cascade is a highly conserved signal transduction module whose activation reportedly...
RAF research is booming since the discovery of mutant B-RAF in ∼8% of human cancer. One reason for t...
Mutations occur in some cancer cells and result in elevated expression or constitutive activation of...
BACKGROUND: The Raf/MAPK kinase/extracellular-signal-regulated kinase pathway is often activated by ...
RAF research is booming since the discovery of mutant B-RAF in ∼8% of human cancer. One reason for t...
The Ras-Raf-MEK-ERK signaling pathway, the first well-established MAPK pathway, plays essential role...
Background: The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signa...
none4siThe Ras/Raf/MEK/ERK cascade is often activated by genetic alterations in upstream signaling m...
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mut...
We discuss the biology of Ras signal transduction and the epidemiology of ras mutations in associati...
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mut...
The mitogen-activated protein kinase (MAPK) signaling pathway plays a critical role in transmitting ...
The Ras/Raf signaling pathway has been recognized as an important process in cancer biology. Recentl...
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mut...
Background: The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signal...
The Raf/MEK/ERK cascade is a highly conserved signal transduction module whose activation reportedly...
RAF research is booming since the discovery of mutant B-RAF in ∼8% of human cancer. One reason for t...
Mutations occur in some cancer cells and result in elevated expression or constitutive activation of...
BACKGROUND: The Raf/MAPK kinase/extracellular-signal-regulated kinase pathway is often activated by ...
RAF research is booming since the discovery of mutant B-RAF in ∼8% of human cancer. One reason for t...
The Ras-Raf-MEK-ERK signaling pathway, the first well-established MAPK pathway, plays essential role...
Background: The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signa...
none4siThe Ras/Raf/MEK/ERK cascade is often activated by genetic alterations in upstream signaling m...
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mut...
We discuss the biology of Ras signal transduction and the epidemiology of ras mutations in associati...
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mut...
The mitogen-activated protein kinase (MAPK) signaling pathway plays a critical role in transmitting ...
The Ras/Raf signaling pathway has been recognized as an important process in cancer biology. Recentl...
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mut...
Background: The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signal...
The Raf/MEK/ERK cascade is a highly conserved signal transduction module whose activation reportedly...
RAF research is booming since the discovery of mutant B-RAF in ∼8% of human cancer. One reason for t...