The Rel/NF-kB family of inducible transcription factors are evolutionarily conserved structurally and functionally, from insects to humans. They are ubiquitously expressed in a number of mature cell types, playing a pivotal role regulating cell growth, differentiation and apoptosis. Under normal circumstances, the proliferation of new cells is tightly regulated, as is the programmed lifespan of most cells, occasionally however cells loose their responsiveness to growth control mechanisms, resulting in a tumor or neoplasm. Sustained or chronic inflammation has been linked to a number of pathological conditions that destroy tissue and facilitate neoplastic growth. NF-kB in part mediates the opposing signals of cell survival and cell death, as...
Kaltschmidt B, Witte K, Greiner J, Weissinger F, Kaltschmidt C. Targeting NF-κB Signaling in Cancer ...
Recent genetic evidence has established a pathogenetic role for NF-kB signaling in cancer. NF-kB sig...
Nuclear transcription factor-κB (NF-κB) represents a family of Rel domain-containing proteins includ...
The Rel/NF-kB family of inducible transcription factors are evolutionarily conserved structurally an...
Tumor cells develop several mechanisms to avoid cell death by various unrelated cytotoxic agents. We...
The ability of the transcription factor NF-kB to upregulate anti-apoptotic proteins has been linked ...
Transcription factors of the NF-κB family are driven by many inflammatory stimuli and activate expre...
Nuclear factor-kappaB (NF-kappaB), a stress-regulated transcription factor belonging to the Rel fami...
The NF-kB pathway is a ubiquitous stress response that activates the NF-kB family of transcription f...
Tumor cells develop several mechanisms to avoid cell death by various unrelated cytotoxic agents. We...
Cancer represents over 200 different diseases of different cell and tissue type origins. The heterog...
The activity of NF-kappaB/Rel transcription factors can downmodulate apoptosis in normal and neoplas...
Importance of the field: The inactive NF-κB–inhibitor of NF-κB (IκB) complex is activated by stimuli...
The transcription factor NF-kB plays a key role in various physiological processes such as immune re...
International audienceNF-kB transcription factors have a key role in many physiological processes, s...
Kaltschmidt B, Witte K, Greiner J, Weissinger F, Kaltschmidt C. Targeting NF-κB Signaling in Cancer ...
Recent genetic evidence has established a pathogenetic role for NF-kB signaling in cancer. NF-kB sig...
Nuclear transcription factor-κB (NF-κB) represents a family of Rel domain-containing proteins includ...
The Rel/NF-kB family of inducible transcription factors are evolutionarily conserved structurally an...
Tumor cells develop several mechanisms to avoid cell death by various unrelated cytotoxic agents. We...
The ability of the transcription factor NF-kB to upregulate anti-apoptotic proteins has been linked ...
Transcription factors of the NF-κB family are driven by many inflammatory stimuli and activate expre...
Nuclear factor-kappaB (NF-kappaB), a stress-regulated transcription factor belonging to the Rel fami...
The NF-kB pathway is a ubiquitous stress response that activates the NF-kB family of transcription f...
Tumor cells develop several mechanisms to avoid cell death by various unrelated cytotoxic agents. We...
Cancer represents over 200 different diseases of different cell and tissue type origins. The heterog...
The activity of NF-kappaB/Rel transcription factors can downmodulate apoptosis in normal and neoplas...
Importance of the field: The inactive NF-κB–inhibitor of NF-κB (IκB) complex is activated by stimuli...
The transcription factor NF-kB plays a key role in various physiological processes such as immune re...
International audienceNF-kB transcription factors have a key role in many physiological processes, s...
Kaltschmidt B, Witte K, Greiner J, Weissinger F, Kaltschmidt C. Targeting NF-κB Signaling in Cancer ...
Recent genetic evidence has established a pathogenetic role for NF-kB signaling in cancer. NF-kB sig...
Nuclear transcription factor-κB (NF-κB) represents a family of Rel domain-containing proteins includ...