The androgen receptor (AR) plays a critical role in prostate cancer. We have identified a ubiquitin E3 ligase, RNF6, as an AR-associated protein in a proteomic screen. RNF6 induces AR ubiquitination and promotes AR transcriptional activity. Specific knockdown of RNF6 or mutation of RNF6-induced ubiquitination acceptor sites on AR selectively alters expression of a subset of AR target genes and diminishes recruitment of AR and its coactivators to androgen-responsive elements present in the regulatory region of these genes. Furthermore, RNF6 is overexpressed in hormone-refractory human prostate cancer tissues and required for prostate cancer cell growth under androgen-depleted conditions. Our data suggest that RNF6-induced ubiquitination may ...
SummaryThe evolution of prostate cancer from an androgen-dependent state to one that is androgen-ind...
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commone...
The classical action of androgen receptor (AR) is to regulate gene transcriptional processes via AR ...
SummaryThe androgen receptor (AR) plays a critical role in prostate cancer. We have identified a ubi...
The androgen receptor (AR) plays a critical role in prostate cancer. We have identified a ubiquitin ...
AbstractAndrogen receptor plays a critical role in the development and maintenance of cancers in the...
Androgen activity plays a key role in prostate cancer progression. Androgen receptor (AR) is the mai...
<div><p>Androgen activity plays a key role in prostate cancer progression. Androgen receptor (AR) is...
Androgen receptor plays a critical role in the development and maintenance of cancers in the prostat...
The androgen receptor (AR) is a ligand-dependent transcription factor. Binding of androgens induces...
Prostate cancer (PCa) primarily depends on androgen receptor (AR) signaling pathway for the initiati...
Previously, we found a novel gene, nuclear receptor interaction protein ( NRIP), a transcription cof...
Prostate cancer is among the most frequently diagnosed malignancies and one of the leading causes of...
Despite androgen deprivation therapy (ADT), persistent androgen receptor (AR) signaling enables outg...
SummaryThe androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the ...
SummaryThe evolution of prostate cancer from an androgen-dependent state to one that is androgen-ind...
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commone...
The classical action of androgen receptor (AR) is to regulate gene transcriptional processes via AR ...
SummaryThe androgen receptor (AR) plays a critical role in prostate cancer. We have identified a ubi...
The androgen receptor (AR) plays a critical role in prostate cancer. We have identified a ubiquitin ...
AbstractAndrogen receptor plays a critical role in the development and maintenance of cancers in the...
Androgen activity plays a key role in prostate cancer progression. Androgen receptor (AR) is the mai...
<div><p>Androgen activity plays a key role in prostate cancer progression. Androgen receptor (AR) is...
Androgen receptor plays a critical role in the development and maintenance of cancers in the prostat...
The androgen receptor (AR) is a ligand-dependent transcription factor. Binding of androgens induces...
Prostate cancer (PCa) primarily depends on androgen receptor (AR) signaling pathway for the initiati...
Previously, we found a novel gene, nuclear receptor interaction protein ( NRIP), a transcription cof...
Prostate cancer is among the most frequently diagnosed malignancies and one of the leading causes of...
Despite androgen deprivation therapy (ADT), persistent androgen receptor (AR) signaling enables outg...
SummaryThe androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the ...
SummaryThe evolution of prostate cancer from an androgen-dependent state to one that is androgen-ind...
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commone...
The classical action of androgen receptor (AR) is to regulate gene transcriptional processes via AR ...