Contrast induced nephropathy and nephrogenic systemic fibrosis

Interventional radiology is currently undergoing significant development.Vascular intrventions in particular have bečíme the method of choice and frequently precede or replace ivasive surgical procedures. Alongside this development, the number of interventions involving the administration of an iodine contrast agent is on the rise. Modern contrast agents are usually well tolerated. Bearing in mind the masive use of these agents, however, we try to prezent thein undesirable effects. In my thesis I deal with the occurrence of contrast-induced nephropathy (CIN) and (NSF).One of the objectives of my work was to examine the occurrence of CIN in the angiography unit at St. Anne´s University Hospital Brno (FN USA), and to evaluate the severity of its course in relation to risk factors infulencing CIN. Another objective was to examine the occurrence of NSF in the Czech Republic. Data from the Hospital Information System of St. Anne´s University Hospital Brno was processed in a methodological procedure. A database was created by identifying patients who underwent a vascular interventional procedure in the angiography unit during the years 2005-2009. Information on the occurrence of NSF in the Czech Republic was obtained from the State Institute for Drug Control and from selected Magnetic Resonance Imaging facilities in the Czech Republic. The results of this work suggest that following preventive measures before the administration of a contrast agent can have a substantial influence on the occurrence of CIN. Moreover, it was confirmed that no case of NSF has occurred in the Czech Republic to date. This work can deepen knowledge of this issue among healthcare professionals and improve the prevention of CIN and NSF