Series of modified nucleosides and oligonucleotides bearing metal complexes were synthetized. Palladium catalyzed aqueous-phase cross-coupling reactions were used as key step in the synthesis of modified metallo-labeled nucleosides, nucleotides and oligonucleotides. The corresponding Fc modified dNTPs were good sustrates for DNA polymerases and were efficiently incorporated to DNA by primer extension (PEX). The modified nucleic acids are applicable as tools in bioanalysis
C8-Arylamine-dG adducts were converted into their corresponding 5′-O-DMTr-3′-O-phosphoramidite-C8-ar...
A method for the enzymatic synthesis of short (10-22 nt) base-modified oligonucleotides was develope...
A series of modified nucleosides bearing the fluorescent substituted biaryl labels attached to nucl...
An efficient methodology of construction of base-modified nucleosides bearing oligopyridine ligands,...
Synthetic modification of nucleoside structures provides access to molecules of interest as pharmace...
An oligonucleotide incorporating a palladacyclic nucleobase has been prepared by ligand-directed met...
The synthesis of novel modified nucleotides and their incorporation into DNA sequences opens many po...
The synthesis of novel modified nucleotides and their incorporation into DNA sequences opens many po...
4 Abstract This work is focused on the synthesis of the modified 2'-deoxyribonucleoside triphosphate...
In the first part of this work, a series of site-specific artificial metallonucleases (AMNs) was dev...
Large-scale genotyping programmes employ fluorescently-labelled nucleoside triphosphates as a means ...
To investigate protein-DNA interactions, we have synthesized a versatile phthalimide-protected 5-(3-...
An efficient two-step methodology for construction of base-modified DNA was developed based on aque...
We employed single step aqueous phase Suzuki-Miyaura cross-coupling reactions of halogenated 2'-deox...
C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemis...
C8-Arylamine-dG adducts were converted into their corresponding 5′-O-DMTr-3′-O-phosphoramidite-C8-ar...
A method for the enzymatic synthesis of short (10-22 nt) base-modified oligonucleotides was develope...
A series of modified nucleosides bearing the fluorescent substituted biaryl labels attached to nucl...
An efficient methodology of construction of base-modified nucleosides bearing oligopyridine ligands,...
Synthetic modification of nucleoside structures provides access to molecules of interest as pharmace...
An oligonucleotide incorporating a palladacyclic nucleobase has been prepared by ligand-directed met...
The synthesis of novel modified nucleotides and their incorporation into DNA sequences opens many po...
The synthesis of novel modified nucleotides and their incorporation into DNA sequences opens many po...
4 Abstract This work is focused on the synthesis of the modified 2'-deoxyribonucleoside triphosphate...
In the first part of this work, a series of site-specific artificial metallonucleases (AMNs) was dev...
Large-scale genotyping programmes employ fluorescently-labelled nucleoside triphosphates as a means ...
To investigate protein-DNA interactions, we have synthesized a versatile phthalimide-protected 5-(3-...
An efficient two-step methodology for construction of base-modified DNA was developed based on aque...
We employed single step aqueous phase Suzuki-Miyaura cross-coupling reactions of halogenated 2'-deox...
C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemis...
C8-Arylamine-dG adducts were converted into their corresponding 5′-O-DMTr-3′-O-phosphoramidite-C8-ar...
A method for the enzymatic synthesis of short (10-22 nt) base-modified oligonucleotides was develope...
A series of modified nucleosides bearing the fluorescent substituted biaryl labels attached to nucl...