The yeast Rgt1 repressor is a bifunctional protein that acts as a transcriptional repressor and activator. Under glucose-limited conditions, Rgt1 induces transcriptional repression by forming a repressive complex with its corepressors Mth1 and Std1. Here, we show that Rgt1 is converted from a transcriptional repressor into an activator under high glucose conditions and this occurs through two independent but consecutive events mediated by two glucose signaling pathways: (1) disruption of the repressive complex by the Rgt2/Snf3 pathway; (2) phosphorylation of Rgt1 by the cAMP-dependent protein kinase (cAMP-PKA) pathway. Rgt1 is phosphorylated by PKA at four serine residues within its amino-terminal region, but this does not occur until the r...
Glucose has dramatic effects on the regulation of carbon metabolism and on many other properties of ...
<p>Transcription of the <i>HXT2</i> gene is repressed by the Rgt1/Ssn6-Tup1 complex in the absence o...
Saccharomyces cerevisiae responds to glucose availability in the environment, inducing the expressio...
The yeast Rgt1 repressor is a bifunctional protein that acts as a transcriptional repressor and acti...
The yeast Rgt1 repressor inhibits transcription of the glucose transporter (HXT) genes in the absenc...
AbstractThe yeast Rgt1 repressor inhibits transcription of the glucose transporter (HXT) genes in th...
The yeast Saccharomyces cerevisiae deploys two different types of glucose sensors on its cell surfac...
Background In yeast, glucose-dependent degradation of the Mth1 protein, a corepressor of the glucose...
Glucose uptake, the first, rate-limiting step of its utilization, is facilitated by glucose transpor...
Glucose is the most abundant monosaccharide and preferred carbon and energy source for most cells. M...
AbstractThe yeast glucose sensors Rgt2 and Snf3 generate a signal in response to glucose that leads ...
Expression of the HXT genes encoding glucose transporters in the budding yeast Saccharomyces cerevis...
The yeast glucose sensors Rgt2 and Snf3 generate a signal in response to glucose that leads to degra...
The yeast HXT (glucose transporter gene) repressor Rgt1 lacks a dimerization domain and thus appears...
Many metabolic diseases are rooted in the inability to process glucose or regulate its uptake. These...
Glucose has dramatic effects on the regulation of carbon metabolism and on many other properties of ...
<p>Transcription of the <i>HXT2</i> gene is repressed by the Rgt1/Ssn6-Tup1 complex in the absence o...
Saccharomyces cerevisiae responds to glucose availability in the environment, inducing the expressio...
The yeast Rgt1 repressor is a bifunctional protein that acts as a transcriptional repressor and acti...
The yeast Rgt1 repressor inhibits transcription of the glucose transporter (HXT) genes in the absenc...
AbstractThe yeast Rgt1 repressor inhibits transcription of the glucose transporter (HXT) genes in th...
The yeast Saccharomyces cerevisiae deploys two different types of glucose sensors on its cell surfac...
Background In yeast, glucose-dependent degradation of the Mth1 protein, a corepressor of the glucose...
Glucose uptake, the first, rate-limiting step of its utilization, is facilitated by glucose transpor...
Glucose is the most abundant monosaccharide and preferred carbon and energy source for most cells. M...
AbstractThe yeast glucose sensors Rgt2 and Snf3 generate a signal in response to glucose that leads ...
Expression of the HXT genes encoding glucose transporters in the budding yeast Saccharomyces cerevis...
The yeast glucose sensors Rgt2 and Snf3 generate a signal in response to glucose that leads to degra...
The yeast HXT (glucose transporter gene) repressor Rgt1 lacks a dimerization domain and thus appears...
Many metabolic diseases are rooted in the inability to process glucose or regulate its uptake. These...
Glucose has dramatic effects on the regulation of carbon metabolism and on many other properties of ...
<p>Transcription of the <i>HXT2</i> gene is repressed by the Rgt1/Ssn6-Tup1 complex in the absence o...
Saccharomyces cerevisiae responds to glucose availability in the environment, inducing the expressio...