Studie úloh TIF34/eIF3i a TIF35/eIF3g subjednotek eIF3 v iniciaci eukaryotické translace

Translation initiation is a multiple-step process involving a large number of soluble eukaryotic initiation factors that ultimately leads to formation of the 80S ribosome with Met-tRNAiMet based paired with the start AUG codon of mRNA. Among the initiation factors, eIF3 draws a special attention since it was shown to promote several critical steps such as recruitment of the eIF2GTPMet-tRNAiMet ternary complex and mRNA to the 40S ribosomal subunit and was implicated in cance