Heart failure with preserved ejection fraction infrequently evolves toward a reduced phenotype in long-term survivors: a long-term prospective longitudinal study
- Lupon, Josep
- Gavidia Bovadilla, Giovana Elizabeth
- de Antonio Ferrer, Marta
- Perera Lluna, Alexandre
- López-Ayerbe, Jorge
- Domingo, Mar Teresa
- Nuñez, Julio
- Zamora, Elisabet
- Moliner, Pedro
- santiago-vacas, Evelyn
- Santemases, Javier
- Bayés Genis, Antoni
DOIAbstract
Long-term trajectories of left ventricular ejection fraction (LVEF) in heart failure (HF) patients with preserved EF (HFpEF) remain unclear. Our objective was to assess long-term longitudinal trajectories in consecutive HFpEF patients and the prognostic impact of LVEF dynamic changes over time.Consecutive ambulatory HFpEF patients admitted to a multidisciplinary HF Unit were prospectively evaluated by 2-dimensional echocardiography at baseline and at 1, 3, 5, 7, 9, and 11 years of follow-up. Exclusion criteria were patients having a previous known LVEF <50%, patients undergoing only 1 echocardiogram study, and those with a diagnosis of dilated, noncompaction, alcoholic, or toxic cardiomyopathy. One hundred twenty-six patients (age, 71±13 ye...
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