Desoctapeptideinsulin (DOI), prepared by tryptic cleavage of porcine insulin, was utilized in the enzyme-catalyzed synthesis of human insulin analogs modified in the C-terminal region of the B-chain
The fully protected octapeptide VII with the amino acid sequence of the human insulin B23-ao chain h...
Insulin is a protein hormone with a pivotal role in the regulation of numerous metabolic processes....
AbstractA yeast expression plasmid encoding a mini-proinsulin molecule was constructed and transform...
The molecule of desoctapeptide insulin is cleaved by ŕ-chymotrypsin at the three tyrosine residues. ...
Insulin remains a challenging synthetic target due in large part to its two-chain, disulfide-constra...
After the discovery of insulin as a drug for diabetes, the pharmaceutical companies were faced with ...
For decades, insulin has represented a preeminent synthetic target. Recently introduced “biomimetic”...
The chemical synthesis of insulin is an enduring challenge due to the hydrophobic peptide chains and...
The preparation of polypeptide and protein analogues by conventional or fragment condensation synthe...
We have synthesized porcine insulin labelled with tritium at position B-30 using enzyme-catalysed fo...
Five protected fragments Ddz-Phe-Val-Asn(Mbh)-Gln(Mbh)-His(Dnp)-Leu-Cys(Acm)-Gly-OH [I], Ddz-Ser(But...
Met-Lys-human proinsulin could be converted into insulin in vitro with the treatment of trypsin and ...
The objective of this thesis is to characterize insulin analogues modified at the C-terminus of th...
A simplified route to synthesis of INSL5 is reported, where the elimination of intermediate purifica...
The discovery of insulin led to a revolution in diabetes management. Since then, many improvements h...
The fully protected octapeptide VII with the amino acid sequence of the human insulin B23-ao chain h...
Insulin is a protein hormone with a pivotal role in the regulation of numerous metabolic processes....
AbstractA yeast expression plasmid encoding a mini-proinsulin molecule was constructed and transform...
The molecule of desoctapeptide insulin is cleaved by ŕ-chymotrypsin at the three tyrosine residues. ...
Insulin remains a challenging synthetic target due in large part to its two-chain, disulfide-constra...
After the discovery of insulin as a drug for diabetes, the pharmaceutical companies were faced with ...
For decades, insulin has represented a preeminent synthetic target. Recently introduced “biomimetic”...
The chemical synthesis of insulin is an enduring challenge due to the hydrophobic peptide chains and...
The preparation of polypeptide and protein analogues by conventional or fragment condensation synthe...
We have synthesized porcine insulin labelled with tritium at position B-30 using enzyme-catalysed fo...
Five protected fragments Ddz-Phe-Val-Asn(Mbh)-Gln(Mbh)-His(Dnp)-Leu-Cys(Acm)-Gly-OH [I], Ddz-Ser(But...
Met-Lys-human proinsulin could be converted into insulin in vitro with the treatment of trypsin and ...
The objective of this thesis is to characterize insulin analogues modified at the C-terminus of th...
A simplified route to synthesis of INSL5 is reported, where the elimination of intermediate purifica...
The discovery of insulin led to a revolution in diabetes management. Since then, many improvements h...
The fully protected octapeptide VII with the amino acid sequence of the human insulin B23-ao chain h...
Insulin is a protein hormone with a pivotal role in the regulation of numerous metabolic processes....
AbstractA yeast expression plasmid encoding a mini-proinsulin molecule was constructed and transform...