Effect of interstimulus interval on cortical proprioceptive responses to passive finger movements

Accepted manuscript online: 28 October 2016Shortening of the interstimulus interval (ISI) generally leads to attenuation of cortical sensory responses. For proprioception, however, this ISI effect is still poorly known. Our aim was to characterize the ISI dependence of movement-evoked proprioceptive cortical responses and to find the optimum ISI for proprioceptive stimulation. We measured, from 15 healthy adults, magnetoencephalographic responses to passive flexion and extension movements of the right index finger. The movements were generated by a movement actuator at fixed ISIs of 0.5, 1, 2, 4, 8, and 16 s, in separate blocks. The responses peaked at ~ 70 ms (extension) and ~ 90 ms (flexion) in the contralateral primary somatosensory cortex. The strength of the cortical source increased with the ISI, plateauing at the 8-s ISI. Modeling the ISI dependence with an exponential saturation function revealed response lifetimes of 1.3 s (extension) and 2.2 s (flexion), implying that the maximum signal-to-noise ratio (SNR) in a given measurement time is achieved with ISIs of 1.7 s and 2.8 s respectively. We conclude that ISIs of 1.5–3 s should be used to maximize SNR in recordings of proprioceptive cortical responses to passive finger movements. Our findings can benefit the assessment of proprioceptive afference in both clinical and research settings.This work was supported by the Academy of Finland (Grants #131483 and #263800 to Riitta Hari and Grants #266133 and #296240 to Harri Piitulainen), Tekes – the Finnish Funding Agency for Technology and Innovation (Grant 1104/10), the European Research Council (Advanced Grant #232946 to Riitta Hari), the Emil Aaltonen Foundation (Eero Smeds), and the Research Programs Unit of the University of Helsinki (Eero Smeds)