Altered working memory-related brain responses and white matter microstructure in extremely preterm-born children at school age
- Tokariev, Maksym
- Vuontela, Virve
- Lönnberg, Piia
- Lano, Aulikki
- Perkola, Jaana
- Wolford, Elina
- Andersson, Sture
- Metsäranta, Marjo
- Carlson, Synnöve
DOIAbstract
Preterm birth poses a risk for neurocognitive and behavioral development. Preterm children, who have not been diagnosed with neurological or cognitive deficits, enter normal schools and are expected to succeed as their term-born peers. Here we tested the hypotheses that despite an uneventful development after preterm birth, these children might exhibit subtle abnormalities in brain function and white-matter microstructure at school-age. We recruited 7.5-year-old children born extremely prematurely (<28 weeks’ gestation), and age- and gender-matched term-born controls (≥37 weeks’ gestation). We applied fMRI during working-memory (WM) tasks, and investigated white-matter microstructure with diffusion tensor imaging. Compared with controls, pr...
Add to ORKG