Add to ORKGThe development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel structures of increased potency. Based on the bioisosterism principle, two novel 2-(5-(naphthalen-1-yl)-1,2,3-thiadiazol-4-ylthio)-N-acetamides derivatives have been designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells. The results indicate that these compounds show good activities against HIV-1. Especially, compound 9B (EC50 = 0.019 μM) was more effective than the reference drugs nevirapine and delavirdine.Colegio de Farmacéuticos de la Provincia de Buenos Aire
The development of novel HIV-1 NNRTIs offers the possibility of generating novel structures with inc...
With continuation of our unremitting efforts toward the discovery of potent HIV-1 NNRTIs, a series o...
Based on the hybridization of the privileged fragments in DABO and DAPY-typed HIV-1 NNRTIs, a novel ...
The development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the p...
A series of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide (TTA) derivatives were synthe...
A series of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide (TTA) derivatives were synthe...
A series of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives (Ia-Im and IIa-IIe) designed...
The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the pos...
As part of our studies to discover new HIV-1 reverse transcriptase inhibitors, a series of 3,4-dichl...
This article reports the design, synthesis and antiviral evaluation of a new series of non-nucleosid...
As part of our studies to discover new HIV-1 reverse transcriptase inhibitors, a series of 3,4-dichl...
On the basis of structural features, binding mode, and structure-activity relationship studies of tw...
On the basis of structural features, binding mode, and structure-activity relationship studies of tw...
This article reports the design, synthesis and antiviral evaluation of a new series of non-nucleosid...
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with novel structures, we...
The development of novel HIV-1 NNRTIs offers the possibility of generating novel structures with inc...
With continuation of our unremitting efforts toward the discovery of potent HIV-1 NNRTIs, a series o...
Based on the hybridization of the privileged fragments in DABO and DAPY-typed HIV-1 NNRTIs, a novel ...
The development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the p...
A series of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide (TTA) derivatives were synthe...
A series of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide (TTA) derivatives were synthe...
A series of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives (Ia-Im and IIa-IIe) designed...
The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the pos...
As part of our studies to discover new HIV-1 reverse transcriptase inhibitors, a series of 3,4-dichl...
This article reports the design, synthesis and antiviral evaluation of a new series of non-nucleosid...
As part of our studies to discover new HIV-1 reverse transcriptase inhibitors, a series of 3,4-dichl...
On the basis of structural features, binding mode, and structure-activity relationship studies of tw...
On the basis of structural features, binding mode, and structure-activity relationship studies of tw...
This article reports the design, synthesis and antiviral evaluation of a new series of non-nucleosid...
In continuation of our efforts toward the discovery of potent HIV-1 NNRTIs with novel structures, we...
The development of novel HIV-1 NNRTIs offers the possibility of generating novel structures with inc...
With continuation of our unremitting efforts toward the discovery of potent HIV-1 NNRTIs, a series o...
Based on the hybridization of the privileged fragments in DABO and DAPY-typed HIV-1 NNRTIs, a novel ...