INTERLEUKIN 1 – B IN GINGIVAL CREVICULAR FLUID AS DIAGNOSTIC MARKER IN PERIODONTAL DISEASE

Abstract. Periodontal disease is chronic multifactorial polymicrobial infection which result in destruction of teeth supporting tissue.C linical diagnosis of periodontal disease is establish by measuring pocket depth, clinical attachment level or bleeding on probing, but this indicator have limitations to provide the real-time evaluation of disease status. Hence, attention is focused on the diagnostic tools that could screen and differentiate the active inflamed sites and predict future tissue destruction. Gingival crevicular fluid has been considered as a medium for early detection of inflammatory cytokines. Interleukin-1β (IL-1 β) which is a vital proinflammatory cytokine plays a major role in inflammation and bone resorption, therefore it becomes an important parameter in periodontal research . Keyword : IL-1B , gingival crevicular fluid, periodontal disease, diagnosti