Add to ORKGObjective:To report the difficulty in achieving and maintaining target antibiotic exposure in critically ill patients with deepseeded infections. Case Summary: We present a case of a 36-year-old man who was admitted to the intensive care unit with diffuse central nervous system and peripheral methicillin-sensitive Staphylococcus aureus infection (minimum inhibitory concentration; MIC, 1 μg/mL). Owing to the complicated nature of the infection, sequential concentrations of free flucloxacillin were measured in plasma and cerebrospinal fluid (CSF) and used to direct antibiotic dosing. Unsurprisingly, the trough plasma concentrations of flucloxacillin were below the MIC (0.2-0.4 μg/mL), and the corresponding CSF concentrations were undetectab...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Infections in critically ill patients are associated with persistently poor clinical outcomes. These...
(See the Editorial Commentary by Craig on pages 1084–5.) Background. Morbidity and mortality for cri...
Objective:To report the difficulty in achieving and maintaining target antibiotic exposure in critic...
Purpose Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Report...
BACKGROUND: Initial appropriate anti-infective therapy is associated with improved outcomes in patie...
Ventriculostomy-associated infections in critically ill patients remain therapeutically challenging ...
Purpose: Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Repor...
OBJECTIVES MSSA bloodstream infections (BSIs) are associated with considerable mortality. Data re...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Ventriculostomy-associated infections, or ventriculitis, in critically ill patients are associated w...
Item does not contain fulltextInfections in critically ill patients are associated with persistently...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Infections in critically ill patients are associated with persistently poor clinical outcomes. These...
(See the Editorial Commentary by Craig on pages 1084–5.) Background. Morbidity and mortality for cri...
Objective:To report the difficulty in achieving and maintaining target antibiotic exposure in critic...
Purpose Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Report...
BACKGROUND: Initial appropriate anti-infective therapy is associated with improved outcomes in patie...
Ventriculostomy-associated infections in critically ill patients remain therapeutically challenging ...
Purpose: Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Repor...
OBJECTIVES MSSA bloodstream infections (BSIs) are associated with considerable mortality. Data re...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Ventriculostomy-associated infections, or ventriculitis, in critically ill patients are associated w...
Item does not contain fulltextInfections in critically ill patients are associated with persistently...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Background. Morbidity and mortality for critically ill patients with infections remains a global hea...
Infections in critically ill patients are associated with persistently poor clinical outcomes. These...
(See the Editorial Commentary by Craig on pages 1084–5.) Background. Morbidity and mortality for cri...